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Hybrid optical-ultrasound scanner for cancer imaging

用于癌症成像的混合光学超声扫描仪

基本信息

批准号：
6918685
负责人：
VASILIS NTZIACHRISTOS
金额：
$ 20.11万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-07-09 至 2007-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6918685
关键词：
biomedical equipment development clinical biomedical equipment early diagnosis fluorescent dye /probe hemodynamics image enhancement laboratory mouse method development model design /development molecular pathology neoplasm /cancer radiodiagnosis neoplasm /cancer therapy neoplastic growth nonhuman therapy evaluation optical tomography phantom model

项目摘要

DESCRIPTION (provided by applicant) Systematic efforts are under way to develop fluorochromes and imaging systems for in-viva examinations of pathogenesis and of treatment at the molecular level. The rationale for such technologies is a) to elucidate molecular mechanisms of disease in unperturbed environments overtime, b) to allow earlier detection of disease based on molecular targets and c) to permit design of patient-specific treatments and monitor therapies on their molecular effect. Recently developed tomographic approaches promise to bring three-dimensional imaging capacity and quantification capability, significantly improving current in-vivo fluorescence detection methods mainly based in planar illumination techniques. fluorescent imaging systems can enable a highly versatile and cost-effective imaging practice and enable the transfer of several elegant in-vitro fluorescent assays to in-vivo application. Similarly to nuclear methods, optical tomography would greatly benefit from the combination of an imaging modality that yields anatomical contrast. From the different important imaging modalities available ultrasound may be a very advantageous alternative. First it interfaces well with optical imaging in that they can be both made extremely portable, small in dimensions and cost-efficient. Second they both use non-ionizing radiation so their combination yields similar operational simplicity. Ultimately a combined ultrasound-optical modality could yield a versatile and economic imaging system that in return can improve the overall current clinical applicability of ultrasound imaging and give simple but high-information imaging solutions to cancer imaging. Pre-clinical evaluation with small animals is proposed herein using high-resolution ultrasound and fluorescence molecular tomography. The hybrid system could offer anatomical information, functional information through ultrasound Doppler imaging and oxy- and deoxy- hemoglobin imaging by the optical system and finally molecular contrast via the use of target specific fluorochromes.

描述(由申请人提供) 目前正在进行系统的努力，以开发荧光染料和成像系统，用于在分子水平上对发病机制和治疗进行体内检查。这种技术的基本原理是a)在不受干扰的环境中长期阐明疾病的分子机制，b)允许基于分子靶标更早地发现疾病，以及c)允许设计针对患者的治疗方法，并监测治疗对其分子效应的影响。最近发展起来的层析成像方法有望带来三维成像能力和量化能力，显著改善目前主要基于平面照明技术的体内荧光检测方法。荧光成像系统可以实现高度通用和成本效益高的成像实践，并能够将几种优雅的体外荧光分析转移到体内应用。与核方法类似，光学层析成像将极大地受益于产生解剖对比的成像方式的组合。从不同的重要成像方式来看，超声可能是一种非常有利的替代方法。首先，它与光学成像很好地结合在一起，因为它们都可以非常便携，尺寸小，成本效益高。其次，它们都使用非电离辐射，因此它们的组合产生了类似的操作简单性。最终，超声和光学的结合可以产生一种通用的、经济的成像系统，反过来可以提高目前超声成像的整体临床适用性，并为癌症成像提供简单但高信息量的成像解决方案。在此建议使用高分辨率超声和荧光分子断层扫描对小动物进行临床前评估。该混合系统可以通过超声多普勒成像提供解剖信息、功能信息，并通过光学系统提供氧合和脱氧血红蛋白成像，最后通过使用靶标特异性荧光染料进行分子对比。