Graduate Training in Cancer Cell Biology

描述（由申请人提供）：本提案要求继续支持基础癌细胞生物学的博士前培训计划。该计划的目标是为在学术机构或行业从事基础或临床相关癌症研究的博士科学家做好准备。培训教师来自细胞和分子医学系（DCMM）、医学和生物系、摩尔斯加州大学圣地亚哥分校癌症中心、路德维希癌症研究所（LICR）和霍华德休斯医学研究所（HHMI）。该学院已经大大扩展到包括活跃在基础和临床前转化癌症研究的教师。该项目是医学院唯一的博士前癌症培训项目，并被整合到生物医学科学（BMS）研究生项目中，因此建立在细胞和分子生物学、遗传学、免疫学、药理学和生理学等广泛基础的项目中。培训教师坚信，要治愈癌细胞中发生的细胞过程紊乱，需要详细了解正常和异常细胞行为的分子、细胞和遗传方面，并将其应用于癌症研究。每一位教师都在他/她的领域得到国际认可，有杰出的培训记录，并且有对理解癌细胞生物学至关重要的研究兴趣-包括细胞周期控制，癌基因和抗癌基因，调节激酶，信号传导，生长控制，G蛋白和RGS蛋白，细胞运动控制，癌细胞糖生物学，内皮生长因子的肿瘤产生，肿瘤血管化，细胞和分子基因组学，以及实验性抗癌疗法的发展。那些在BMS研究生课程的第一年就表示有兴趣进行基础癌细胞生物学论文研究的个人，将根据其学术和研究表现的实力进行选择。学员需要完成BMS研究生课程的要求和专门的癌症培训生项目的要求，包括癌症研究课程，负责任的研究行为，癌症细胞/分子生物学的教程和小组会议，参加DCMM联合系列研讨会以及关于癌症临床方面和肿瘤细胞对各种治疗反应的系列研讨会。

DESCRIPTION (provided by applicant): This proposal requests continuing support for a predoctoral training program in basic Cancer Cell Biology. The program goal is to prepare Ph.D. scientists for careers in basic or clinically-related Cancer Research in academic institutions or industry. The training faculty are drawn from the Departments of Cellular and Molecular Medicine (DCMM), Medicine and Biology, the Moores UCSD Cancer Center, the Ludwig Institute for Cancer Research (LICR), and the Howard Hughes Medical Institute (HHMI). The faculty has been greatly expanded to include faculty active in both basic and preclinical translational cancer research. This program is the only predoctoral cancer training program based in the School of Medicine and is integrated into the Biomedical Sciences (BMS) Graduate Program and is therefore built on and integrated within a broadly based program in cell and molecular biology, genetics, immunology, pharmacology and physiology. The training faculty strongly believes that to cure the derangements of cell processes that occur in cancer cells requires detailed understanding of the molecular, cellular and genetic aspects of both normal and abnormal cell behavior and their application to cancer research. Each of the faculty is internationally recognized in his/her field, has an outstanding training record, and has research interests that are fundamental to understanding cancer cell biology- including cell cycle control, oncogenes and anti-cancer genes, regulatory kinases, signaling, growth control, G proteins and RGS proteins, control of cell movement, glycobiology of cancer cells, tumor production of endothelial growth factors, tumor vascularization, cellular and molecular genomics, and the development of experimental anticancer therapeutics. Those individuals who during their first year in the BMS graduate program express an interest in undertaking thesis research in basic cancer cell biology are selected for support based on the strength of their academic and research performance. Trainees are required to complete both the BMS Graduate Program requirements and the specialized Cancer Trainee Program requirements, including courses in Cancer Research, the Responsible Conduct of Research, tutorials and small group conferences on the cellular/molecular biology of cancer, and attendance at the joint DCMM seminar series as well as a seminar series on the clinical aspects of cancer and the response of tumor cells to various treatments.