Nickel Catalysis with Sterically-Hindered Substrates

镍催化为合成化学提供了许多机会，包括进入新化学空间的新反应，以及取代昂贵和不太环保的重金属(如钯)。然而，这一领域的进展需要对镍催化的范围和局限性有详细的了解，并需要进一步的工作来克服这些限制。本项目将审查涉及空间受阻的芳基卤化物的镍催化反应。由这类底物制成的产品可能具有有价值的生物学特性，但目前能够使用这些底物的镍催化反应的例子相对较少。在这次学生合作的过程中，我们将对相关的反应机理和结构/反应关系有一个基本的了解，利用这些信息开发下一代镍催化反应，并在化学工业中产生影响。

Nickel catalysis offers many opportunities for synthetic chemistry, including new reactions to access new chemical space, and the replacement of expensive and less green heavy metals (such as palladium). However, progress in the field requires a detailed understanding of the scope and limitations of nickel catalysis and further work to overcome these limitations.This project will examine nickel-catalysed reactions that involve sterically-hindered aryl halides. Products that are made from this class of substrate might have valuable biological properties but at present there are relatively few examples of nickel-catalysed reactions that can deploy these substrates.During the course of this studentship collaboration we will develop a fundamental understanding of relevant reaction mechanisms and structure/reactivity relationships, use this information to develop the next generation of nickel-catalysed reactions, and deliver impact in the chemical industry.