Software For The Analysis Of Hormone Pulsatility

激素脉动分析软件

• 批准号: 6922083
• 负责人: MICHAEL Linn JOHNSON
• 金额: $ 46.09万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6922083
• 关键词: Internet; automated data processing; computer graphics /printing; computer human interaction; computer program /software; computer simulation; computer system design /evaluation; educational resource design /development; hormone metabolism; interactive multimedia; method development; statistics /biometry; workshop

DESCRIPTION (provided by applicant): This proposal will create an integrated software package for investigation of hormone concentration-time series by further development, extension, validation, and distribution of the data analysis algorithms and software created by our group over the last twenty years. These programs explore the aperiodic fluctuations that are typical for serum concentration profiles of many neuroendocrine and peripherally secreted hormones. Extensive experimental and theoretical work documents the physiological importance of these fluctuations that could be altered by pathophysiology, or could mediate key intra- and interspecies distinctions. However, the evolving demands of endocrine researchers cannot be adequately addressed by our current programs, which are based on outdated computer platforms, user interfaces, and lack extensive documentation. Accordingly, we propose to develop an integrated package of advanced data analysis algorithms, attendant software and documentation for multifaceted investigation of endocrine concentration-time series. The suite will encompass established and modem algorithms, as well as a contemporary user interface to facilitate the application by clinical investigators. In addition, the software and documentation will be freely accessible for research purposes. To meet these goals, we intend to upgrade our existing software to utilize a modern user interface in the framework of MS-Windows NT/2000/XP operating system (Aim 1). Inclusion of contemporary algorithms. (Aim 2) will expand the software capabilities and provide more precision, additional information, and increased user functionality. Special emphasis will be placed on improving the raw data preprocessing techniques (Aim 3), and on validation and testing of the new algorithms with simulated and experimental data (Aim 5). Extensive documentation will be created to ensure proper understanding and usage of the software and to facilitate future modifications by us and/or other investigators (Aim 4). The software and documentation will be available as we expand our World Wide Web presence (Aim 6). Improving and expanding our annual "Workshop on the Analysis of Hormone Pulsatility". (Aim 7) will further popularize the software package and supply essential feedback. This effort will provide the endocrine research community with contemporary, easy-to-use, computer- based tools for studying, individually or jointly, various characteristics of a single or multiple related hormone concentration-time series. We also envision potential applications in other non-endocrine research fields.

描述（由申请人提供）：本提案将通过进一步开发、扩展、验证和分发我们小组在过去二十年中创建的数据分析算法和软件，创建一个用于激素浓度-时间序列研究的集成软件包。这些程序探讨了许多神经内分泌和外周分泌激素的血清浓度曲线的典型非周期性波动。大量的实验和理论工作证明了这些波动的生理重要性，这些波动可以通过病理生理学改变，或者可以介导关键的种内和种间差异。然而，内分泌研究人员不断变化的需求不能充分满足我们目前的计划，这是基于过时的计算机平台，用户界面，并缺乏广泛的文档。因此，我们建议开发一个集成的软件包，先进的数据分析算法，伴随的软件和文件的多方面的调查内分泌浓度的时间序列。该套件将包括已建立的和调制解调器的算法，以及一个当代的用户界面，以促进临床研究者的应用。此外，软件和文件将免费提供用于研究目的。为了实现这些目标，我们打算升级我们现有的软件，以便在MS-Windows NT/2000/XP操作系统的框架内利用现代用户界面（目标1）。包含当代算法。(Aim 2）将扩展软件功能，提供更精确的附加信息，并增加用户功能。特别强调将放在改进的原始数据预处理技术（目标3），并验证和测试的新算法与模拟和实验数据（目标5）。将创建大量文档，以确保正确理解和使用软件，并方便我们和/或其他研究者将来进行修改（目标4）。软件和文档将随着我们扩大万维网的存在而提供（目标6）。改进和扩大我们的年度“激素脉动分析研讨会”。(Aim 7）进一步推广软件包，提供必要的反馈。这项工作将为内分泌研究界提供当代的、易于使用的、基于计算机的工具，用于单独或联合研究单个或多个相关激素浓度-时间序列的各种特征。我们还设想了在其他非内分泌研究领域的潜在应用。