Technoeconomically Optimal and Environmentally Benign Pharmaceutical Manufacturing at High Process Mass Intensity (PMI)

爱丁堡大学(UOE)和一家大型跨国制药公司的这项合作研究项目将使用高保真数值模拟来捕获、模拟、可视化和优化高过程质量密度(PMI)下高价值活性药物成分(API)制造流程图的设计和操作，以实现可持续和环境友好的药物生产。通过减少溶剂使用量实现可见的原料药生产强化是可行的，但确保稳定(例如没有堵塞)有效的单元操作是由此带来的挑战。更高效的批次和更低的溶剂库存减少了浪费，从而提高了产量和盈利能力。该博士项目的目的是在硅胶中评估溶剂选择、流程配置(工艺合成)和库存对原料药工厂效率的影响：这可以改变游戏规则，使用严格的动力学参数估计和分离热力学的统一框架。产业安置和协作是该项目不可或缺的一部分。

This collaborative research project between the University of Edinburgh (UoE) and a major multinational pharmaceutical company will employ high-fidelity numerical modelling to capture, simulate, visualise and optimise the design and operation of high-value Active Pharmaceutical Ingredient (API) manufacturing flowsheets at high Process Mass Intensity (PMI), towards the sustainable and environmentally benign production of medications.Viable API production intensification is feasible by reducing solvent usage, yet ensuring stably (e.g. no clogging) efficient unit operations is the resulting challenge. More efficient batches at lower solvent inventory reduce waste for higher throughput and profitability. The purpose of this PhD project is to assess in silico the effect of solvent choices, flowsheet configuration (process synthesis) and inventories on API plant efficiency: this can be a game changer, using a unified framework of rigorous kinetic parameter estimation and separation thermodynamics. Industrial placement and collaboration form an integral part of this project.