Therapeutic Intermittent Hypoxia effects on neurovascular health and metabolism.

治疗性间歇性缺氧对神经血管健康和新陈代谢的影响。

• 批准号: 2589784
• 金额: --
• 依托单位: Bangor University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2589784
• 关键词: Therapeutic; Intermittent; Hypoxia; effects; neurovascular

This PhD project aims to investigate two therapeutic interventions (mild intermittent hypoxia and mild physiologic stress through exercise) to maintain cognitive function across the lifespan. As the proposed protective mechanisms for the intervention involves similar changes to brain metabolism and cerebrovascular responses, the project will utilise multi-modal imaging techniques (magnetic resonance imaging, transcranial doppler ultrasound and near infrared spectroscopy) to characterise these proposed brain changes, and how these may relate to improvements in cognitive function.

该博士项目旨在研究两种治疗干预（轻度间歇性缺氧和通过运动的轻度生理应激），以维持整个生命周期的认知功能。由于拟议的干预保护机制涉及大脑代谢和脑血管反应的类似变化，该项目将利用多模态成像技术（磁共振成像，经颅多普勒超声和近红外光谱）来验证这些拟议的大脑变化，以及这些变化如何与认知功能的改善有关。