Development of an organ-chip to study regulation of primary cilia mechanobiology as novel treatment of Polycystic Kidney Disease

开发器官芯片来研究初级纤毛机械生物学的调节作为多囊肾病的新疗法

• 批准号: 2590836
• 金额: --
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2590836
• 关键词: Development; organ; chip; study; regulation

This studentship provides an exciting opportunity to join a team of biomedical scientists and bioengineers using organ-chip technology to investigate primary cilia and test new therapies. The project will test the hypothesis that pharmaceutical elongation of primary cilia in kidney epithelial cells enhances essential mechanotransduction. The student will examine whether this can compensate for the genetic disruption of cilia that causes Polycystic Kidney Disease (PKD).

这个奖学金提供了一个令人兴奋的机会，加入一个生物医学科学家和生物工程师团队，使用器官芯片技术研究初级纤毛和测试新疗法。该项目将测试这一假设，即药物延长初级纤毛在肾脏上皮细胞增强必要的机械转导。学生将检查这是否可以补偿导致多囊肾病（PKD）的纤毛遗传破坏。