Mechanisms of cell to cell spread of Marek's Disease Virus

马立克氏病病毒细胞间传播的机制

• 批准号: 2590886
• 金额: --
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2590886
• 关键词: Mechanisms; cell; spread; Marek; Disease

"Marek's disease is a fatal, highly contagious, neoplastic disease affecting chickens that is a significant economic burden threatening sustainable food production. It is caused by an alphaherpesvirus called Gallid herpesvirus-2 or Marek's Disease Virus (MDV). The disease is managed by tight biosecurity practices in industrial poultry forming and in ovo vaccination. Failure of the current vaccine strategy would threaten global poultry production.MDV is strictly cell-associated and produces hardly any cell-free virions. The mechanisms of cell-to-cell spread are not understood. Here we aim to directly visualise cell-to-cell spread of MDV, identify receptors and host factors that are required for MDV transmission. We anticipate that this work will identify host factors that could be targeted to establish MDV-resistant livestock in the future. "

“马立克氏病是一种致命的、高度传染性的肿瘤性疾病，影响鸡，是一个重大的经济负担，威胁着可持续粮食生产。它是由称为鸡疱疹病毒-2或马立克氏病病毒（MDV）的α疱疹病毒引起的。该疾病是通过严格的生物安全措施在工业家禽形成和卵内疫苗接种管理。目前疫苗策略的失败将威胁全球家禽生产。MDV是严格的细胞相关的，几乎不产生任何无细胞病毒粒子。细胞间扩散的机制尚不清楚。在这里，我们的目标是直接可视化MDV的细胞间传播，识别MDV传播所需的受体和宿主因子。我们预计，这项工作将确定宿主因素，可以有针对性地建立MDV抗性牲畜在未来。"