Mechanisms of cell to cell spread of Marek's Disease Virus

马立克氏病是一种致命的、高度传染性的肿瘤性疾病，影响着鸡，是威胁可持续食品生产的重大经济负担。它是由一种名为加利德疱疹病毒-2或马立克氏病病毒(MDV)的甲型疱疹病毒引起的。该疾病通过严格的生物安全措施在工业家禽形成和疫苗接种中进行管理。当前疫苗策略的失败将威胁全球家禽生产。MDV严格与细胞相关，几乎不产生任何无细胞的病毒粒子。细胞间传播的机制尚不清楚。在这里，我们的目标是直接可视化MDV在细胞间的传播，识别MDV传播所需的受体和宿主因素。我们预计，这项工作将确定未来可能有针对性地建立抗MDV牲畜的宿主因素。“

"Marek's disease is a fatal, highly contagious, neoplastic disease affecting chickens that is a significant economic burden threatening sustainable food production. It is caused by an alphaherpesvirus called Gallid herpesvirus-2 or Marek's Disease Virus (MDV). The disease is managed by tight biosecurity practices in industrial poultry forming and in ovo vaccination. Failure of the current vaccine strategy would threaten global poultry production.MDV is strictly cell-associated and produces hardly any cell-free virions. The mechanisms of cell-to-cell spread are not understood. Here we aim to directly visualise cell-to-cell spread of MDV, identify receptors and host factors that are required for MDV transmission. We anticipate that this work will identify host factors that could be targeted to establish MDV-resistant livestock in the future. "