Diet and reproductive factors influencing ageing

秀丽隐杆线虫是研究寿命和健康寿命的极好模型，因为它易于遗传操作，寿命短，易于实验室饲养。通过去除其生殖系并在饮食限制下培养，其寿命增加2-3倍。线虫在这些条件下介导寿命增加的机制知之甚少。在这个项目中，学生将进行基因筛选，以确定潜在的寿命延长调节剂。

Caenorhabditis elegans is an excellent model for studying lifespan and healthspan because of its amenability to genetic manipulation, short lifespan, and ease in laboratory husbandry. By removing its germline and culturing under diet restriction, its lifespan increases 2-3-fold. The mechanisms mediating increase of lifespan when nematodes are under those conditions are poorly understood. In this project, the student will perform genetic screens to identify potential modulators of lifespan extension.