Diet and reproductive factors influencing ageing

影响衰老的饮食和生殖因素

• 批准号: 2590914
• 金额: --
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2590914
• 关键词: Diet; reproductive; factors; influencing; ageing

Caenorhabditis elegans is an excellent model for studying lifespan and healthspan because of its amenability to genetic manipulation, short lifespan, and ease in laboratory husbandry. By removing its germline and culturing under diet restriction, its lifespan increases 2-3-fold. The mechanisms mediating increase of lifespan when nematodes are under those conditions are poorly understood. In this project, the student will perform genetic screens to identify potential modulators of lifespan extension.

秀丽隐杆线虫是研究其寿命和健康寿命的一个很好的模型，因为它易于遗传操作，寿命短，易于实验室饲养。通过去除其生殖系并在饮食限制下培养，其寿命延长2-3倍。线虫在这些条件下延长寿命的机制尚不清楚。在这个项目中，学生将进行基因筛选，以确定潜在的寿命延长调节因子。