MR Method for Determining Magnetic Field Correlation

确定磁场相关性的 MR 方法

• 批准号: 6930105
• 负责人: JENS H JENSEN
• 金额: $ 21.02万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6930105
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical research; contrast media; human subject; magnetic field; magnetic resonance imaging; method development; phantom model

DESCRIPTION (provided by applicant): The broad goal of the research is to develop a new magnetic resonance imaging (MRI) contrast mechanism based on a quantity called the magnetic field correlation (MFC). The MFC is a measure of how the local magnetic field experienced by water molecules changes as the molecules diffuse through a biological tissue. The MFC can give, for example, information about the microscopic (cellular scale) distribution of iron in the brain, which may be useful in studying a variety of neurodegenerative pathologies, including Alzheimer's and Parkinson's diseases, that are associated with brain iron abnormalities. MFC imaging, when used in conjunction with a paramagnetic contrast agent, may also aid in evaluating tumors. Although the MFC is related to quantities, such as relaxation rates and diffusion constants that can be estimated with standard MR/techniques, there is currently no established method of determining the MFC. The contrast observed in an MFC image will differ from that obtained with standard MR/techniques, and MFC imaging can be regarded as providing a new contrast mechanism. The first phase of the research will be the implementation, optimization, and validation our proposed MFC imaging method. The validation will be accomplished by performing a series of imaging experiments with two types of synthetic models (phantoms). The phantom types will be aqueous suspensions, one with yeast cells and one with polystyrene microspheres. For both types, a paramagnetic contrast agent will be used to systematically adjust the magnetic field inhomogeneities. A careful comparison will be made between the acquired imaging data and the predictions of the theory upon which MFC imaging is based. For the polystyrene microsphere suspensions, the measured MFC can be compared directly, without the use of fitting parameters, to theoretically predicted values. The second phase of the research will demonstrate in vivo MFC imaging in 20 normal human subjects. For all the subjects, MFC images will be obtained of a brain slice containing the basal ganglia. The measured MFC values will be compared with model predictions based on histology and prior MR/studies. The means and standard deviations of the MFC values will be calculated for the subject pool. This will provide baseline data for the application of MFC imaging to neurological disorders.

描述（由申请人提供）： 这项研究的主要目标是开发一种新的磁共振成像（MRI）对比机制，该机制基于一种称为磁场相关性（MFC）的量。 MFC是当水分子扩散通过生物组织时，水分子所经历的局部磁场如何变化的量度。 MFC可以给出例如关于铁在脑中的微观（细胞尺度）分布的信息，这可以用于研究与脑铁异常相关的各种神经退行性病理，包括阿尔茨海默病和帕金森病。 当与顺磁性造影剂结合使用时，MFC成像也可以帮助评估肿瘤。 尽管MFC与可以用标准MR/技术估计的诸如弛豫速率和扩散常数的量有关，但是目前没有确定MFC的方法。 在MFC图像中观察到的对比度将不同于用标准MR/技术获得的对比度，并且MFC成像可以被认为提供了新的对比度机制。 研究的第一阶段将是实施、优化和验证我们提出的MFC成像方法。 验证将通过使用两种类型的合成模型（体模）进行一系列成像实验来完成。 体模类型将是水性悬浮液，一种含有酵母细胞，一种含有聚苯乙烯微球。 对于这两种类型，将使用顺磁性造影剂来系统地调节磁场不均匀性。一个仔细的比较，将获得的成像数据和预测的理论MFC成像的基础上。 对于聚苯乙烯微球悬浮液，测量的MFC可以直接比较，而不使用拟合参数，理论预测值。 研究的第二阶段将在20名正常人受试者中展示体内MFC成像。 对于所有受试者，将获得包含基底神经节的脑切片的MFC图像。 将测量的MFC值与基于组织学和既往MR/研究的模型预测值进行比较。 将计算受试者汇总的MFC值的平均值和标准差。 这将为MFC成像在神经系统疾病中的应用提供基线数据。