Super Resolution FA Retinal Imager

超分辨率 FA 视网膜成像仪

• 批准号: 6933964
• 负责人: Gavin Erry
• 金额: $ 15.38万
• 依托单位: KESTREL CORPORATION
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6933964
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; clinical research; eye fundus photography; fluorescein angiography; human subject

DESCRIPTION (provided by applicant): The project has two Aims in Phase I. The first Aim is to modify an existing adaptive optics fundus imager to create the first Super Resolution Fluorescein Angiography Retinal Imager (SFARI) device. This modified instrument will allow fluorescein retinal imaging with up to 3 microns spatial resolution at rates of 10 images per second over a 20 deg field of view. The second Aim is to conduct laboratory testing using artificial eyes and standard references to quantitatively measure the spatial and temporal resolution gains that this new SFARI device provides and certify the instrument for use on human subjects, and to demonstrate the performance of the SFARI using two normal human subjects. The proposed SFARI device is a revolutionary step forward in the field of clinical in-vivo imaging of the retina and retinal substructures at micron-scale spatial resolutions and with video (10 Hz) frame rates. The project introduces innovative adaptive optics technology to an important new application, fluorescein angiography. Successful completion will represent a significant contribution to clinical and research ophthalmology. Fluorescein angiography and indocyanine green imaging of the retina are a common procedure in most ophthalmology clinics making the commercial potential high with the device having a market that includes every major eye clinic in the U.S. and abroad.

项目描述（由申请人提供）：该项目在第一阶段有两个目标。第一个目标是修改现有的自适应光学眼底成像仪，以创建第一个超分辨率血管造影视网膜成像仪（SFARI）设备。这种改进的仪器将允许荧光素视网膜成像，空间分辨率高达3微米，在20度视场内每秒10幅图像。第二个目标是使用人工眼睛和标准参考进行实验室测试，以定量测量这种新的SFARI设备提供的空间和时间分辨率增益，并证明该仪器可用于人类受试者，并使用两个正常的人类受试者来证明SFARI的性能。所提出的SFARI设备是视网膜和视网膜子结构在微米级空间分辨率和视频（10 Hz）帧速率下的临床体内成像领域的革命性一步。该项目将创新的自适应光学技术引入到一个重要的新应用中，即荧光素血管造影。成功完成将代表对临床和研究眼科学的重大贡献。视网膜的血管造影术和吲哚菁绿色成像是大多数眼科诊所中的常见程序，使得该装置具有很高的商业潜力，其市场包括美国和国外的每个主要眼科诊所。