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Noise-Isolating Capsule for Small-Animal fMRI Research

用于小动物功能磁共振成像研究的噪声隔离舱

基本信息

批准号：
6989000
负责人：
ERIC EDWARD UNGAR
金额：
$ 9.85万
依托单位：
ACENTECH, INC.
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-12 至 2007-03-11
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6989000
关键词：
animal research subject auditory stimulus bioimaging /biomedical imaging biomaterial development /preparation biomaterial evaluation brain imaging /visualization /scanning brain metabolism functional magnetic resonance imaging magnetic resonance imaging microcapsule neuropsychology neurotoxicology noise stressor substance abuse related disorder

项目摘要

DESCRIPTION (provided by applicant): The project's long-term objective is to provide a capsule that will permit functional magnetic resonance imaging (fMRI) to be carried out on test animals conveniently without subjecting these animals to the stresses associated with the acoustic noise produced by MRI equipment. Such a capsule will facilitate imaging research on animal models to identify brain changes associated with the use and abuse of psychoactive substances, since acoustic noise stress interacts with the effects of these substances. A proof-of-principle capsule of a clear plastic will be built to accommodate a small primate and fit into a typical MRI system. Acoustical measurement equipment that can operate reliably in a MRI scanner's intense magnetic fields will be obtained and its performance will be verified. The intial capsule will be provided with various acoustic barrier arrangements consisting of double-wall structures and resilient layers topped by massive layers, with acoustically absorptive layers added on the exterior. The noise isolating performance of these barrier arrangements will be measured, modeled analytically, and optimized -- both for conventional scanning and for scanning protocols that generate acoustic noise in only limited frequency ranges. Detailed design of two prototype capsules with high acoustic attenuation will be carried out. The design will take account of non-acoustical requirements, such as the need to observe the test subject, the need to clean and disinfect the capsule, and accommodation of animals of slightly different sizes. An initial study aimed at enhancing the capsule's noise isolation performance by active control means will be performed. This study will address sensor and actuator locations and types, the transfer functions between these, and the control logic.

描述（由申请人提供）：该项目的长期目标是提供一种胶囊，可以方便地在实验动物身上进行功能性磁共振成像（fMRI），而不会使这些动物受到与MRI设备产生的噪声相关的应力。这种胶囊将促进动物模型的成像研究，以确定与使用和滥用精神活性物质有关的大脑变化，因为噪音压力与这些物质的作用相互作用。将建造一个透明塑料制成的原理验证胶囊，以容纳小型灵长类动物，并适合典型的MRI系统。将获得能够在MRI扫描仪强磁场中可靠工作的声学测量设备，并对其性能进行验证。最初的胶囊将提供各种音障安排，由双层结构和弹性层组成，顶部是块状层，并在外部添加吸声层。这些屏障布置的噪声隔离性能将被测量，分析建模，并优化-无论是传统扫描还是在有限频率范围内产生噪声的扫描协议。将对两个高声衰减原型舱进行详细设计。设计将考虑到非声学方面的要求，如观察实验对象的需要，对胶囊进行清洁和消毒的需要，以及容纳大小略有不同的动物。初步研究旨在通过主动控制手段提高胶囊的隔声性能。本研究将讨论传感器和执行器的位置和类型，它们之间的传递函数，以及控制逻辑。