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Directed Delivery of Growth Factors to the CNS

Directed Delivery of Growth Factors to the CNS
生长因子定向输送至中枢神经系统
批准号：
6934761
负责人：
ANDREW BAIRD
金额：
$29.02万
依托单位：
TERA BIOTECHNOLOGY CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
项目状态：
已结题
起止时间：
2005-07-15 至 2006-06-30
来源：
https://reporter.nih.gov/project-details/6934761
关键词：
6 hydroxydopamineParkinson&aposs diseaseautoradiographybiotechnologybiotherapeutic agentblood brain barrierbrain disorder chemotherapycell proliferationcombinatorial chemistrydisease /disorder modeldrug delivery systemsdrug design /synthesis /productiondrug screening /evaluationepidermal growth factorimmunocytochemistryinhalation drug administrationlaboratory ratnerve stem cellnervous system regenerationneuropharmacologic agentnonhuman therapy evaluationphage displaypharmacokineticstransforming growth factorswestern blottings

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DESCRIPTION (provided by applicant): Certain proteins, like growth factors have significant potential to treat neurodegenerative disease. Accordingly, it should be possible to stimulate the growth of endogenous progenitor stem cells so that they could enhance the natural course of injury repair. Unfortunately, the blood brain barrier forms a significant hurdle that limits the clinical utility of most peptides. We propose to apply principles of medicinal biology and combinatorial pharmacology to improve the delivery of growth factors to the brain and describe a comprehensive strategy to address a major problem in the development of CNS biotherapeutics: drug delivery to the brain.
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