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Directed Delivery of Growth Factors to the CNS

Directed Delivery of Growth Factors to the CNS
生长因子定向输送至中枢神经系统
批准号：
6934761
负责人：
ANDREW BAIRD
金额：
$29.02万
依托单位：
TERA BIOTECHNOLOGY CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
项目状态：
已结题
起止时间：
2005-07-15 至 2006-06-30
来源：
https://reporter.nih.gov/project-details/6934761
关键词：
6 hydroxydopamineParkinson&aposs diseaseautoradiographybiotechnologybiotherapeutic agentblood brain barrierbrain disorder chemotherapycell proliferationcombinatorial chemistrydisease /disorder modeldrug delivery systemsdrug design /synthesis /productiondrug screening /evaluationepidermal growth factorimmunocytochemistryinhalation drug administrationlaboratory ratnerve stem cellnervous system regenerationneuropharmacologic agentnonhuman therapy evaluationphage displaypharmacokineticstransforming growth factorswestern blottings

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相关文献

中文摘要
翻译
描述（由申请人提供）：某些蛋白质，如生长因子，具有治疗神经退行性疾病的显著潜力。因此，刺激内源性祖干细胞的生长应该是可能的，这样它们就可以增强损伤修复的自然过程。不幸的是，血脑屏障形成了一个重要的障碍，限制了大多数肽的临床应用。我们建议应用药物生物学和组合药理学的原则，以提高交付的生长因子的大脑和描述一个全面的战略，以解决一个主要问题，在发展中的中枢神经系统生物治疗药物：药物输送到大脑。
英文摘要
DESCRIPTION (provided by applicant): Certain proteins, like growth factors have significant potential to treat neurodegenerative disease. Accordingly, it should be possible to stimulate the growth of endogenous progenitor stem cells so that they could enhance the natural course of injury repair. Unfortunately, the blood brain barrier forms a significant hurdle that limits the clinical utility of most peptides. We propose to apply principles of medicinal biology and combinatorial pharmacology to improve the delivery of growth factors to the brain and describe a comprehensive strategy to address a major problem in the development of CNS biotherapeutics: drug delivery to the brain.
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会议论文
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Targeting the choroid plexus for drug translocation into CSF
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