Arterial Cannula with Permissive Distal Perfusion

描述（由申请人提供）：将开发一种新型插管设计，用于在动脉插管期间提供远端灌注。动脉插管在体外血液处理的几种应用中是常见的。然而，由于插管部位远端的动脉灌注不足，将插管放置在动脉中有组织损伤的风险。在本申请中提出了一种独特的解决方案，其中插管将被设计和制造为具有可变膨胀阻力球囊，该可变膨胀阻力球囊将在插管周围形成流动通道以从插管向下游灌注。将使用计算流体动力学设计和评价插管。将组装套管原型并进行血液动力学和完整性试验。这种设计方法将允许插管尺寸最大化，这将最大限度地减少体外回路的阻力，同时确保患者的安全。此外，可变阻力球囊可以适应波动的流量要求。这种套管设计可以在体外气体交换和灌注支持系统中提供直接益处。在血液滤过、血液透析和肝脏支持系统中可能有可能扩展用途。

DESCRIPTION (provided by applicant): A novel cannula design will be developed to provide distal perfusion during arterial cannulation. Arterial cannulation is common in several applications of extracorporeal blood processing. However, placement of a cannula in an artery risks tissue damage due to inadequate perfusion of the artery distal to the cannulation site. A unique solution is presented in this application, where a cannula will be designed and fabricated with a variable inflation resistor balloon that will form flow channels around the cannula to perfuse downstream from the cannula. The cannula will be designed and evaluated using computational fluid dynamics. Prototypes of the cannula will be assembled and tested for hemodynamics and integrity. This design approach will allow for the cannula size to be maximized, which will minimize the resistance of the extracorporeal circuit, while ensuring safety for the patient. In addition, the variable resistance balloon can accommodate fluctuating flow requirements. This cannula design can provide immediate benefits in extracorporeal gas exchange and perfusion support systems. Possible expanded uses are possible in hemofiltration, hemodialysis, and liver support systems.