PhenoNet: Distributed Repositories for Phenotypic Data
PhenoNet:表型数据的分布式存储库
基本信息
- 批准号:6936635
- 负责人:
- 金额:$ 16.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2004
- 资助国家:美国
- 起止时间:2004-08-15 至 2006-08-14
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): The goal of this project is to investigate the technical feasibility and commercial potential of a platform (PhenoNet) for custom phenotypic data repositories that encourages adoption of phenotypic data standards and exchange of knowledge across sources.
Phenotypic data collection today generates large quantities of heterogeneous data and it does not yet match the analogous efforts in genomic research in terms systematization or throughput. Freimer and Sabbati's recently proposed Human Phenome Project will require "an enormous coordinated effort, to obtain phenomic databases that are powerful, standardized, and comprehensive" (2003). PhenoNet will be used by individual investigators or laboratories and will provide users with tools to administer projects, enter data, track progress, and create complex queries. The true significance of the system, however, will be in enabling users to define and map their datasets to accepted standards for phenotypic data, and then share and integrate datasets via these standards. The platform will increase the pace at which research can occur by streamlining the dataset design process, facilitating increased accuracy and throughput in phenotypic data collection, and providing detailed auditing and tracking of the data collection processes. The system will provide an enhanced ability to store, manipulate, and share phenotypic data.
An adjunct PhenoNet "Registry" will serve as a centralized directory of investigators with standards compliant datasets, enabling researchers to find collaborators and integrate disparate data based on common mapping to accepted standards. In doing so, PhenoNet will allow for novel research designs by facilitating data mining of detailed phenotypic datasets in ways that are currently prohibitively complex. By examining data in these new ways, investigators will be able to produce more granular characterizations of expressed traits that can lead to more effective analysis when studying genetic or environmental influences on disease as well as refinement and better understanding of disease phenotypes. Phase I will include analysis and design of all major components of the system as well as construction and evaluation of a prototype system in the field of psychiatric and neurological research.
描述(由申请人提供):该项目的目标是调查平台(PhenoNet)的技术可行性和商业潜力,用于定制表型数据存储库,鼓励采用表型数据标准和跨来源的知识交流。
今天的表型数据收集产生了大量的异质性数据,它还没有匹配的系统化或吞吐量方面的基因组研究中的类似努力。Freimer和Sabbati最近提出的人类表型组计划将需要“巨大的协调努力,以获得功能强大,标准化和全面的表型数据库”(2003)。PhenoNet将由个人研究者或实验室使用,并将为用户提供管理项目、输入数据、跟踪进度和创建复杂查询的工具。然而,该系统的真正意义在于使用户能够定义和映射他们的数据集到公认的表型数据标准,然后通过这些标准共享和整合数据集。该平台将通过简化数据集设计过程,促进提高表型数据收集的准确性和吞吐量,并提供详细的审计和跟踪数据收集过程,加快研究的步伐。该系统将提供存储、操作和共享表型数据的增强能力。
一个附属的PhenoNet“Registry”将作为一个集中的研究人员目录,提供符合标准的数据集,使研究人员能够找到合作者,并根据通用映射将不同的数据整合到公认的标准。在这样做的过程中,PhenoNet将通过以目前过于复杂的方式促进详细表型数据集的数据挖掘来实现新颖的研究设计。通过以这些新的方式检查数据,研究人员将能够对所表达的性状进行更精细的表征,从而在研究遗传或环境对疾病的影响以及对疾病表型的细化和更好的理解时进行更有效的分析。第一阶段将包括分析和设计该系统的所有主要组成部分,以及在精神病学和神经学研究领域建造和评估原型系统。
项目成果
期刊论文数量(0)
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专利数量(0)
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{{ truncateString('CAL T COLLINS', 18)}}的其他基金
OpenClinica: Open Source Platform for Clinical Research
OpenClinica:临床研究开源平台
- 批准号:
8005812 - 财政年份:2010
- 资助金额:
$ 16.4万 - 项目类别:
PhenoNet: Distributed Repositories for Phenotypic Data
PhenoNet:表型数据的分布式存储库
- 批准号:
6790736 - 财政年份:2004
- 资助金额:
$ 16.4万 - 项目类别:
OpenClinica: Open Source Platform for Clinical Research
OpenClinica:临床研究开源平台
- 批准号:
7329355 - 财政年份:2004
- 资助金额:
$ 16.4万 - 项目类别:
OpenClinica: Open Source Platform for Clinical Research
OpenClinica:临床研究开源平台
- 批准号:
7478849 - 财政年份:2004
- 资助金额:
$ 16.4万 - 项目类别:
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