ANTIGEN PRESENTATION IN CEREBRAL MALARIA PATHOGENESIS: A ROLE FOR BRAIN MICROVASCULAR ENDOTHELIUM AND MICROPARTICLES

脑疟疾发病机制中的抗原呈递：脑微血管内皮和微粒的作用

• 批准号: nhmrc : 1099920
• 负责人: Dr Bernadette Saunders
• 金额: $ 28.51万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/antigen-presentation-cerebral-endothelium-microparticles/662478
• 关键词: ANTIGEN; PRESENTATION; CEREBRAL; MALARIA; PATHOGENESIS

We want to better understand how lesions occur in the brain during cerebral malaria. We focus our attention on the cells lining the brain blood vessels, called endothelial cells. The originality of this project is to study endothelial cells as immune cells. We already showed that they carry molecules enabling them to activate T lymphocytes and trigger inflammation. Knowing the fine mechanisms by which small brain vessels become damaged will help design better treatments for neuroinflammation.

我们想更好地了解脑疟疾期间大脑中的病变是如何发生的。我们把注意力集中在内衬脑血管的细胞上，叫做内皮细胞。该项目的独创性在于将内皮细胞作为免疫细胞进行研究。我们已经证明它们携带的分子能够激活T淋巴细胞并引发炎症。了解小脑血管受损的精细机制将有助于设计更好的治疗神经炎症的方法。