Communication within the membrane during complement activation

补体激活过程中膜内的通讯

• 批准号: 2595046
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2595046
• 关键词: Communication; within; membrane; during; complement

The membrane attack complex (MAC) is one of the immune system's first responders. Complement proteins assemble on target microbial or self-cell membranes to form pores that lyse pathogens and affect tissue homeostasis. While MAC assembly is known to cause changes in some key membrane mechanical properties, there remain significant questions about the protein - membrane interplay and interactions that bring about these changes and the impact that membrane - protein co-structuring has on a wealth of other physiologically critical biophysical membrane parameters. Understanding these biophysical mechanisms is critical to developing new strategies to intervene in complement immune deficiencies that have devastating consequences for human health. Here, we will use newly developed approaches to investigate the effect of MAC assembly on key biophysical parameters of biological and biomimetic membranes, and the feedback of these changes on the subsequent MAC assembly steps and eventual membrane rupture.

膜攻击复合体(MAC)是免疫系统的第一反应之一。补体蛋白聚集在目标微生物或自身细胞膜上，形成毛孔，溶解病原体，影响组织动态平衡。虽然已知MAC组装会导致一些关键的膜机械性质的变化，但关于引起这些变化的蛋白质-膜相互作用和相互作用以及膜-蛋白质共结构对其他许多生理关键的生物物理膜参数的影响仍然存在重大问题。了解这些生物物理机制对于开发干预补体免疫缺陷的新策略至关重要，补体免疫缺陷对人类健康具有毁灭性的后果。在这里，我们将使用新开发的方法来研究MAC组装对生物膜和仿生膜的关键生物物理参数的影响，以及这些变化对后续MAC组装步骤和最终膜破裂的反馈。