Women's Ischemia Syndrome Evaluation

女性缺血综合症评估

• 批准号: 6879942
• 负责人: Sheryl F Kelsey
• 金额: $ 63.08万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6879942
• 关键词: angiography; cardiovascular disorder diagnosis; cardiovascular disorder epidemiology; cooperative study; cost effectiveness; diagnosis design /evaluation; electrocardiography; gender difference; hormone regulation /control mechanism; human data; human subject; interview; longitudinal human study; myocardial ischemia /hypoxia; outcomes research; pathologic process; patient oriented research; prognosis; women' s health

This reapplication proposes to extend the follow-up of the Women's Ischemia Syndrome Evaluation (WISE) patients for a minimum of 5 years and is being submitted jointly with the applications "Altered Renin Angiotensin System as a Mechanism for Coronary Microvascular Dysfunction in Women" (C. Pepine PI) and "Immunologic Basis For Coronary Disease in Women" (S.Reis PI). The WISE contract began in September 1996 as a 4-center study to 1) optimize symptom evaluation and diagnostic testing for ischemic heart disease in women; 2) explore mechanisms for symptoms and myocardial ischemia in the absence of epicardial coronary artery stenoses; and 3) evaluate the influence of reproductive hormones on symptoms and diagnostic test response. An extensive contemporary database has been assembled on 936 women referred for coronary angiography because of suspected ischemia. Data include demographic, clinical, sympotmatic, functional, and psychosocial variables. Coronary angiography and ventriculography data, brachial artery reactivity testing, ECG monitoring, and blood determinations are all assessed by core laboratories. Site-specific innovative technologies have been used to develop potential markers of myocardial ischemia. We seek to 1) Determine the incremental long-term prognostic value of novel testing developed in WISE; 2) Develop sex-specific incremental outcome models to evaluate the prognostic value of female reproductive variables; 3) Assess the incremental cost effectiveness and resources efficiency of the WISE innovative testing techniques as compared with traditional tests; 4) Continue ongoing analyses and ancillary projects, collaborate with other WISE investigators Ro1's submitted in this cluster, and maintain a WISE database and infrastructure to facilitate further investigations into the mechanisms underlying ischemia syndromes in women. To address these aims, a longer follow-up is necessary. Follow-up will consist of annual telephone contacts by experienced site coordinators. WISE will continue to use the well-established methods to implement study coordination, data management, quality control, statistical analyses, and manuscript preparation. Cox regression models will be used as explanatory variables. A hybrid decision model will be used that compares resource use patterns and sums cost estimates. The results of these studies will enhance our understanding of both the significance and pathophysiology of ischemic heart disease in women and serve as a foundation for diagnostic and therapeutic clinical trials aimed at reducing disease-related morbidity and mortality.

该重新申请建议将女性缺血综合征评估（WISE）患者的随访时间延长至少5年，并与申请"改变的肾素血管紧张素系统作为女性冠状动脉微血管功能障碍的机制"（C. Pepine PI）和"女性冠状动脉疾病的免疫学基础"（S. Reis PI）。 WISE合同开始于1996年9月，作为一项4中心研究，1）优化女性缺血性心脏病的症状评估和诊断测试; 2）在没有心外膜冠状动脉狭窄的情况下探索症状和心肌缺血的机制; 3）评估生殖激素对症状和诊断测试反应的影响。 一个广泛的当代数据库已经收集了936名妇女提到冠状动脉造影，因为怀疑缺血。 数据包括人口统计学、临床、症状、功能和心理社会变量。 冠状动脉造影和心室造影数据、肱动脉反应性检测、ECG监测和血液测定均由核心实验室进行评估。 特定部位的创新技术已被用于开发心肌缺血的潜在标志物。 我们寻求1）确定WISE开发的新检测的增量长期预后价值; 2）开发性别特异性增量结局模型以评估女性生殖变量的预后价值; 3）评估WISE创新检测技术与传统检测相比的增量成本效益和资源效率; 4）继续进行分析和辅助项目，与其他WISE研究人员Ro1在这一集群中提交的合作，并维护WISE数据库和基础设施，以促进进一步调查妇女缺血综合征的机制。 为了实现这些目标，需要更长时间的后续行动。 随访将包括由经验丰富的研究中心协调员进行的年度电话联系。 WISE将继续使用完善的方法来实施研究协调、数据管理、质量控制、统计分析和手稿准备。 将使用考克斯回归模型作为解释变量。将使用一个混合决策模式，比较资源使用模式和费用估计数。 这些研究的结果将增强我们对女性缺血性心脏病的意义和病理生理学的理解，并为旨在降低疾病相关发病率和死亡率的诊断和治疗性临床试验奠定基础。

项目成果

Microvascular dysfunction: What have we learned from WISE?

微血管功能障碍：我们从 WISE 中学到了什么？

• DOI: 10.1586/erc.11.165
• 发表时间: 2011
• 期刊: Expert review of cardiovascular therapy
• 影响因子: 2
• 作者: Park,KiE;Pepine,CarlJ
• 通讯作者: Pepine,CarlJ

Mortality Risk Associated With Resistant Hypertension Among Women: Analysis from Three Prospective Cohorts Encompassing the Spectrum of Women's Heart Disease.

与女性难治性高血压相关的死亡风险：对涵盖女性心脏病谱系的三个前瞻性队列进行分析。

• DOI: 10.1089/jwh.2015.5609
• 发表时间: 2016
• 期刊: Journal of women's health (2002)
• 作者: Smith,StevenM;Huo,Tianyao;Gong,Yan;Handberg,Eileen;Gulati,Martha;Merz,CNoelBairey;Pepine,CarlJ;Cooper-DeHoff,RhondaM
• 通讯作者: Cooper-DeHoff,RhondaM

Adenosine vs Regadenoson Pharmacologic Stress Differs in Women with Suspected Coronary Microvascular Dysfunction: A Report from the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction (WISE-CVD) Study.

• DOI: 10.31487/j.cdm.2019.01.01
• 发表时间: 2019-01-01
• 期刊: Cardiovascular disorder and medicine
• 作者: Wei, Janet;Jalnakupur, Sawan;Merz, C Noel Bairey
• 通讯作者: Merz, C Noel Bairey

Mental Stress and Myocardial Ischemia: Young Women at Risk.

精神压力和心肌缺血：年轻女性面临风险。

• DOI: 10.1161/jaha.116.004196
• 发表时间: 2016
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Wokhlu,Anita;Pepine,CarlJ
• 通讯作者: Pepine,CarlJ