THE BOSTON HAPPENS ADOLESCENT MEDICINE TRIALS UNIT

在美国，感染艾滋病毒/艾滋病的青少年人数继续上升，越来越多的经围产期传播艾滋病毒的儿童活到青春期和青年期。 波士顿大都市受到艾滋病毒/艾滋病的极大影响，并遵循了年轻妇女、男青年和有色人种青年人数不断增加的全国趋势。 波士顿艾滋病毒提供者和同伴教育服务网络青少年医学试验单位（AMTU）已经建立，为大都市地区12-24岁的年轻人提供临床试验和研究的机会。 AMTU设在波士顿儿童医院青少年/年轻成人部，有一个专门针对青少年的艾滋病毒护理提供者小组，他们将在波士顿医疗中心儿童医院和小悉尼博勒姆健康中心提供服务。儿童医院和波士顿医疗中心在青少年实践中为不同人群提供服务，包括有色人种青年、年轻女性、围产期感染青年和同性恋/双性恋青年。 小悉尼·博勒姆号保健中心特别向同性恋/双性恋和变性青年以及街头青年提供护理。 波士顿HAPPENS计划的广泛合作网络使年轻人能够在青少年环境中接受护理。 该项目的具体目标是：（1）招募和保留75名感染艾滋病毒的青年进行艾滋病毒/艾滋病网络研究，（2）招募和保留125名适当的对照人员，（3）参与制定艾滋病毒/艾滋病网络研究议程，（4）建立专家和社区咨询委员会，（5）加强波士顿大都市的艾滋病毒护理和研究工作。 目前，我们有71名艾滋病毒呈阳性（12-23岁，60%为女性，60%为女性，75%为黑人）接受护理，预计到2000年7月1日，将有90名艾滋病毒呈阳性，以及125名对照受试者。 我们与儿科艾滋病临床试验组（PACTG），青少年PACTG倡议和波士顿HAPPENS计划的长期经验使我们能够接触大量青少年，并在艾滋病毒护理，治疗方案，研究和临床试验方案方面拥有丰富的经验。 此外，我们期待着与现有的研究网络和青少年医学试验网络密切合作，以帮助制定青少年和年轻人的科学议程。

The numbers of adolescents living with HIV/AIDS continue to rise in the United States with more children with perinatally transmitted HIV increasing surviving to the adolescent and young adult years. Metropolitan Boston has been greatly impacted by HIV/AIDS and has followed the national trends of increasing numbers of young women, young men who have sex with men, and youth of color. The Boston HAPPENS' (Boston HIV Provider and Peer Education Network for services) Adolescent Medicine Trials Unit (AMTU) has been developed to provide access to clinical trials and research for young people 12-24 years old in the metropolitan area. The AMTU is housed in the Adolescent/Young Adult Division, Children's Hospital, Boston, with a single team of adolescent- specific HIV care providers who will offer services at Children's Hospital, Boston Medical Center and the Sydney Borum, Jr, Health Center. Children's Hospital and Boston Medical Center serve diverse populations including youth of color, young women, perinatally infected youth and gay/bisexual youth in their Adolescent Practices. The Sydney Borum, Jr., Health Center particularly provides care to gay/bisexual and transgender youth and street involved youth. The broad collaborative network of the Boston HAPPENS Program allows for the ongoing connection for young people to receive care in adolescent settings. The specific aims of this project are to: 1) recruit and retain 75 HIV infected youth for ATN studies, 2) recruit and retain 125 appropriate controls, 3) participate in the development of the ATN research agenda, 4) establish expert and community advisory boards, and 5) strengthen HIV care and research efforts in metro-Boston. We currently have 71 HIV positive (12-23 years old, 60% female old, 60% female, 75% black) in care, project by July 1, 2000 that will have 90 HIV positive as well as 125 control subjects. Our long term experience with the Pediatric AIDS Clinical Trials Group (PACTG), the Adolescent PACTG initiative, and the Boston HAPPENS Program allow us to have access to large numbers of adolescents and extensive experience with HIV care, treatment regimens, research, and clinical trials protocols. In addition, we look forward to working closely with the existing research network and the Adolescent Medicine Trials Network to help develop the scientific agenda for adolescents and young adults.