Towards broad-spectrum antimicrobial vaccines: uniting automated and enzymatic glycan assembly for the synthesis and bioconjugation of bacterial exopo

迈向广谱抗菌疫苗：将自动化和酶促聚糖组装结合起来，用于细菌外泌体的合成和生物共轭

• 批准号: 2595945
• 金额: --
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2595945
• 关键词: Towards; broad; spectrum; antimicrobial; vaccines

In this project we propose to unite two novel strategies for synthesis of complex carbohydrates, automated and enzymatic glycan assembly, in the construction of antigenic bacterial polysaccharides for the development of an enabling technology for vaccine construction. There is a pressing need for antibodies and vaccines of improved efficacy, and improved methods for their production. This project is aimed at creating a new enabling technology for controlled synthesis of a carbohydrate-protein vaccine conjugate in pursuit of a broad-spectrum antimicrobial vaccine

在这个项目中，我们提出了两种新的策略，用于合成复杂的碳水化合物，自动化和酶促聚糖组装，在抗原性细菌多糖的构建中，用于开发疫苗构建的使能技术。迫切需要具有改进功效的抗体和疫苗，以及用于它们的生产的改进方法。该项目旨在创造一种新的使能技术，用于控制合成碳水化合物-蛋白质疫苗缀合物，以追求广谱抗菌疫苗