How the Bcl-2 protein family controls apoptosis and impacts on cancer development and therapy

Bcl-2 蛋白家族如何控制细胞凋亡以及对癌症发展和治疗的影响

• 批准号: nhmrc : 1041797
• 负责人: Prof Jerry Adams
• 金额: $ 56.7万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bcl-2-protein-development-therapy/111393
• 关键词: How; Bcl; protein; family; controls

Impaired cell death (apoptosis) is now recognized as an important step towards cancer and a major barrier to effective therapy. The discoveries on apoptosis by Professor Jerry Adams and colleagues have galvanized the search for drugs that engage the cell’s apoptotic machinery as a new way to treat cancer. His proposed studies aim to clarify how apoptosis is controlled and how the control goes awry in cancer, and to determine how such drugs can be most effectively used to improve cancer treatment.

受损的细胞死亡（凋亡）现在被认为是迈向癌症的重要一步，也是有效治疗的主要障碍。Jerry亚当斯教授和他的同事们关于细胞凋亡的发现激发了人们对参与细胞凋亡机制的药物的研究，作为治疗癌症的新方法。他提出的研究旨在阐明细胞凋亡是如何控制的，以及这种控制在癌症中是如何出错的，并确定如何最有效地使用这些药物来改善癌症治疗。