Advanced Optical Techniques to Probe the Effect of Molecular Crowding on Lipid Membrane Dynamics

先进光学技术探测分子拥挤对脂质膜动力学的影响

• 批准号: 2596385
• 金额: --
• 依托单位: University of York
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2596385
• 关键词: Advanced; Optical; Techniques; Probe; Effect

The state-of-the-art single-molecule technologies developed in York can now, for the first time, beapplied to address previously intractable biological questions involving vesicle conformation and activity.Furthermore, the PhD student will work closely with Quinn to establish a new ultrafast spectroscopy facility withinthe Department which will also serve to benefit internal (Krauss, Wang, Cavill, Kröger) and external (Johnson, Leech,Moore, Baumann) academics. The work will also seed a major EPSRC Early Career Fellowship in support of Quinn(2022), at least 2 EPSRC responsive mode bids (ca. £500k each) in EPSRC priority areas and will afford asustainable collaboration between Leake and Quinn over a 3+ year timeframe. We also require a PhD student tocomplete experiments in support of at least 1 imminent high impact paper and 2-4 future publications. This projectwill also add substantive value to the department given the recent growth of the Physics of Life team and newlaboratories, and will strengthen links with the York Biomedical Research Institute, as well as others across multipledepartments. At the time of writing, we have received four applications from potential PhD students, all of whom arehighly motivated and competent individuals, and three of whom are on target for excellent 1st class awards. Allcandidates are, however, reliant on funding. Please note at the time of writing this application, Dr. Steve Quinn is inthe process of supervising his first PhD student at York (2020- 2023) and Prof. Leake will act in capacity of supportinghim and the candidate throughout this exciting programme of research.

约克大学开发的最先进的单分子技术现在可以第一次应用于解决以前棘手的涉及囊泡构象和活性的生物学问题。此外，该博士生将与Quinn密切合作，在系内建立一个新的超快光谱设备，这也将有利于内部（Krauss, Wang, Cavill, Kröger）和外部（Johnson, Leech,Moore, Baumann）学者。这项工作还将为Quinn提供一个主要的EPSRC早期职业奖学金（2022年），在EPSRC优先领域至少有2个EPSRC响应模式投标（每个约50万英镑），并将在3年多的时间内为Leake和Quinn提供可持续的合作。我们还要求博士生完成至少1篇即将发表的高影响力论文和2-4篇未来出版物的实验。鉴于最近生命物理团队和新实验室的增长，该项目还将为该部门增加实质性价值，并将加强与约克生物医学研究所以及多个部门之间的联系。在撰写本文时，我们已经收到了四名潜在博士生的申请，他们都是非常积极和有能力的人，其中三名是优秀的一等奖项的目标。然而，所有候选人都依赖于资金。请注意，在撰写本申请时，Steve Quinn博士正在指导他在约克大学的第一个博士生（2020- 2023），Leake教授将在整个令人兴奋的研究项目中为他和候选人提供支持。