Advanced Optical Techniques to Probe the Effect of Molecular Crowding on Lipid Membrane Dynamics

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The state-of-the-art single-molecule technologies developed in York can now, for the first time, beapplied to address previously intractable biological questions involving vesicle conformation and activity.Furthermore, the PhD student will work closely with Quinn to establish a new ultrafast spectroscopy facility withinthe Department which will also serve to benefit internal (Krauss, Wang, Cavill, Kröger) and external (Johnson, Leech,Moore, Baumann) academics. The work will also seed a major EPSRC Early Career Fellowship in support of Quinn(2022), at least 2 EPSRC responsive mode bids (ca. £500k each) in EPSRC priority areas and will afford asustainable collaboration between Leake and Quinn over a 3+ year timeframe. We also require a PhD student tocomplete experiments in support of at least 1 imminent high impact paper and 2-4 future publications. This projectwill also add substantive value to the department given the recent growth of the Physics of Life team and newlaboratories, and will strengthen links with the York Biomedical Research Institute, as well as others across multipledepartments. At the time of writing, we have received four applications from potential PhD students, all of whom arehighly motivated and competent individuals, and three of whom are on target for excellent 1st class awards. Allcandidates are, however, reliant on funding. Please note at the time of writing this application, Dr. Steve Quinn is inthe process of supervising his first PhD student at York (2020- 2023) and Prof. Leake will act in capacity of supportinghim and the candidate throughout this exciting programme of research.