Baylor-Cayetano Heredia Training Program in Global Infe*

描述(申请人提供)：这是为全球传染病研究培训计划提交的新培训补助金。该计划将利用贝勒医学院(BCM)丰富的研究环境，培养来自赫雷迪亚大学热带医学研究所(IMT)的优秀医生。培训将侧重于IMT针对的疾病，利用BCM在腹泻疾病和免疫寄生虫学的临床和实验室调查方面正在进行的研究机会。一个由IMT教员领导的委员会每年将挑选一名学员参加拟议的培训计划，该委员会基于候选人突出的学术潜力和返回秘鲁在IMT工作的全球传染病方面的承诺。每名学员将在BCM接受为期两年的严格科学培训。学员将报名参加BCM研究生院和BCM的NIH K30支持的临床医生科学家培训计划的课程，为他们提供强大的免疫学或流行病学、临床研究负责人和研究伦理方面的知识基础。受训者将在假设驱动的研究、准备出版手稿、在全国会议上发表演讲、准备拨款提案和学术生涯发展方面得到全面指导。免疫寄生虫学的受训人员将在BCM炎症生物学中心工作，该中心包括20,000平方英尺的连续、新装修的实验室空间，容纳了高度互动的研究人员和受训人员，专注于免疫反应。导师从NIH资助的中心首席研究人员中挑选出来，将提供与肠道原虫和蠕虫感染相关的人类粘膜免疫反应、细胞免疫学以及细胞因子/趋化因子相互作用方面的培训。有关腹泻疾病的培训将在德克萨斯大学公共卫生学院的传染病中心进行。受训者将与正在进行的旅行者和流行人群腹泻疾病的国际调查合作，或与美国国立卫生研究院赞助的BCM疫苗治疗评估单位的肠道挑战核心合作。所有学员和他们的BCM导师将被要求在第二年的培训期间提交资助申请。在第三年，学员将在IMT教员的最初6个月内获得工资支持，使他们有时间建立独立的研究议程，并有时间建立合作。该培训计划的目标是培养和指导致力于全球传染病研究的内科科学家，为他们提供获得独立资金所需的工具，并指导他们成为全球传染病领域的国际领导者。

DESCRIPTION (provided by applicant): This is a new training grant submitted for the Global Infectious Disease Research Training Program. This program will take advantage of the rich investigative environment at Baylor College of Medicine (BCM) to train outstanding physicians from the Institute of Tropical Medicine (IMT), Universidad Peruana Cayetano Heredia. Training will focus on diseases targeted by IMT, taking advantage of ongoing research opportunities in clinical and laboratory investigation at BCM in diarrheal diseases and immunoparasitology. One trainee will be selected to enter the proposed training program per year by a committee headed by IMT faculty based on the candidate's outstanding academic potential and commitment to return to Peru to work at IMT in global infectious diseases. Each trainee will undergo 2 years of rigorous scientific training at BCM. Trainees will enroll in courses from BCM's graduate school and BCM's NIH K30-supported clinician scientist training program, providing them a strong knowledge base in immunology or epidemiology, principals of conducting clinical research, and ethical conduct of research. Trainees will be comprehensively mentored in hypothesis-driven research, preparation of manuscripts for publication, presentations at national meetings, preparation of grant proposals, and academic career development. Trainees in immunoparasitology will work in the BCM Biology of Inflammation Center, which includes 20,000 sq ft of contiguous, newly renovated laboratory space and houses a highly interactive critical mass of investigators and trainees, focused on the immune response. Mentors, selected from NIH-funded principal investigators in the center, will provide training in the human mucosal immune response, cellular immunology and cytokine/chemokine interactions related to intestinal protozoan and helminth infections. Training in diarrheal disease will be based at the Center for Infectious Diseases, at the University of Texas School of Public Health. Trainees will work in collaboration with ongoing international investigations of diarrheal diseases in travelers and endemic populations or with the NIH-sponsored enteric challenge core of the BCM vaccine treatment evaluation unit. All trainees and their BCM mentors will be required to submit grant applications during the second year of training. During a third year, trainees will receive salary support during their initial 6 months on the IMT faculty, allowing them protected time to establish independent research agendas and time to establish collaborations. The goals of this training program are to develop and mentor physician-scientists committed to global infectious diseases, to provide them with the tools needed to obtain independent funding, and mentor them as international leaders in global Infectious Diseases.