Mechanisms of IL-18 Mediated Regulation of GVHD and GVL

IL-18介导的GVHD和GVL调节机制

• 批准号: 6886918
• 负责人: PAVAN REDDY
• 金额: $ 12.24万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6886918
• 关键词: MHC class I antigen; MHC class II antigen; apoptosis; bone marrow transplantation; cellular immunity; cytokine; cytolysins; cytotoxic T lymphocyte; cytotoxicity; enzyme linked immunosorbent assay; flow cytometry; graft versus host disease; helper T lymphocyte; homologous transplantation; immunoregulation; interferon gamma; interferon inducers; laboratory mouse; leukemia; nitric oxide; oxidoreductase inhibitor; pathologic process; pore forming protein; transcription factor

DESCRIPTION (provided by applicant): This is an application for a K08 award. The candidate,Dr. Pavan Reddy, is a junior faculty member in the Blood and Marrow Stem Cell Transplantation Program at the University of Michigan. Dr. Reddy's long-term goal is to become an independent laboratory investigator in the field of experimental bone marrow transplantation (BMT)and graft versus host disease (GVHD). This application details a four point program that will provide the necessary tools for Dr. Reddy to develop his research career such that he can achieve this goal and eventually become a leader in adult bone marrow transplantation. First, the applicant will obtain advanced conceptual and theoretical background in cellular and molecular immunology with particular emphasis on lymphocyte and cytokine biology by participating in several immunology courses in the University of Michigan graduate school. Second, the applicant will acquire additional BMT research skills and techniques through the completion of his research project regarding the modulation of acute GVHD by IL-18. Dr. Reddy has already achieved impressive preliminary data from this project that have been published in the Journal of Experimental Medicine. Third, the applicant will acquire advanced communication skills, both written and oral, required for a successful research career through participation in BMT research seminars and conferences, participation in national Hematology and BMT meetings and the preparation of scientific manuscripts. Fourth, the applicant's progress throughout the award will be monitored by an advisory committee of senior researchers and academic leaders. The applicant's sponsor guarantees that 80% of Dr. Reddy's effort will be devoted to his research during this award.

描述（由申请人提供）：这是一份申请K08奖的申请。博士候选人。Pavan Reddy是密歇根大学血液和骨髓干细胞移植项目的初级教员。Reddy博士的长期目标是成为实验性骨髓移植（BMT）和移植物抗宿主病（GVHD）领域的独立实验室研究者。这份申请详细介绍了一个四点计划，将为Reddy博士提供必要的工具，以发展他的研究事业，使他能够实现这一目标，并最终成为成人骨髓移植领域的领导者。