MOUNT SINAI-NEW YORK STATE - ARGENTINA HIV PREVENTION PR

西奈山医学院（MSSM）正在重新提交一份申请，以响应福格蒂国际中心的艾滋病国际培训和研究项目申请：TW-00-003。该方案的主要目的是为阿根廷艾滋病毒/结核病预防研究培训制定一个广泛而深入的方法。该建议包括以下方面的培训：1)生物医学预防/基础研究；2)行为和社会医学预防研究，3)数据管理和分析，以及4)可以借鉴基础，生物和行为科学的转化研究。我们的“自下而上”、“自上而下”的方法将研究、培训和资源与基于社区的战略设置联系起来。所提出的模式旨在建立机制/基础设施，以发展一个持续的交流系统，以便在北美和南美保健提供系统内部和整个系统中产生和整合新的预防知识。目标是：1)支持美国学术研究中心与阿根廷站点之间的持续合作，以发展当地研究能力和合作艾滋病毒/结核病预防研究培训；2)建立阿根廷主要利益相关者与美国研究人员之间的长期合作关系；3)在阿根廷受艾滋病毒/艾滋病和结核病影响较严重的地区建立关键的生物医学和行为科学专业知识；4)确定阿根廷将艾滋病毒初级、二级或三级预防进展纳入临床和社区环境的“错失的机会”；5)培训个人进行“介入性研究”，以便迅速纳入研究结果，影响系统层面的变化；(6)通过建立合作网络，开展临床试验，以解决通过我们的合作关系可接触到的人群的具体问题；(7)将培训方法发展为一种模式，应用于其他环境（城市、州和国家）。该项目将在五年的资助期内为被选中的候选人提供各种类型的多学科培训机会。受训者将参加一个结合教学和体验的研究培训项目。在指定的阿根廷和/或美国导师的指导下，每个受训人员将在以下领域之一开展一个研究项目：a)预防围产期艾滋病毒传播；b)通过性传播疾病的二级预防来初级预防艾滋病毒；(c)通过控制感染预防血液传播疾病；d)发展生成可靠数据集的能力；e)结核病的预防、诊断和治疗；f)艾滋病毒/结核病的临床、诊断和基础研究。阿根廷/美国联盟由MSSM（在西奈山/纽约大学卫生系统内）、纽约州立大学奥尔巴尼分校、纽约卫生部艾滋病研究所与布宜诺斯艾利斯国立大学、临床医院、Huesped基金会、费尔南德斯医院、加拉汉姆医院和帕罗西森医院以及罗萨里奥国立大学（阿根廷圣达菲）组成。

The Mount Sinai School of Medicine (MSSM) is re-submitting an application in response to the Fogarty International Centers' AIDS International Training and Research Program Request for Applications: TW-00-003. The principal aim of the program is to develop a broad and deep approach for prevention research training in HIV/TB in Argentina. The proposal includes training in: 1) biomedical prevention/basic research; 2) behavioral and sociomedical prevention research, 3) data management and analysis, and 4) translational research that can draw upon basic, biologic and behavioral science. Our "bottom-up," "top-down" approach links research training and resources with strategic community based settings. The model proposed seeks to establish mechanisms/infrastructure for developing a sustained exchange system for generating and integrating new prevention knowledge within and across the North and South American health-care delivery systems. The goals are to: 1) Support sustained cooperation between US academic research centers and Argentine sites for the development of local research capacity and collaborative HIV/TB prevention research training; 2) Establish long-term cooperative relationships between key Argentine stakeholders and US researchers; 3) Establish critical biomedical and behavioral science expertise in areas of Argentina more severely affected by HIV/AIDS and TB; 4) Identify "missed opportunities" for the integration of advances in HIV primary, secondary or tertiary prevention into clinical and community settings in Argentina; 5) Train individuals in the conduct of "interventional research" so as to allow the rapid incorporation of findings to affect system-level changes; (6) Enable, through the establishment of a collaborative network, the conduction of clinical trials designed to address issues specific to the populations made accessible through our partnership: 7) Develop the training approach as a model to be applied in other settings (cities, states, and countries). The program will offer selected candidates a variety of types of multi-disciplinary training opportunities throughout the five-year period of the grant. Trainees will participate in a combined didactic and experiential research-training program. Under the guidance of assigned Argentine and/or US mentors, each trainee will develop a research project in one of the following areas: a) Prevention of perinatal HIV transmission; b) Primary prevention of HIV through secondary prevention of STDs; c) Prevention of blood borne diseases through infection control; d) Capacity development for the generation of reliable data sets; e) Prevention, diagnosis and treatment of TB; and f) Clinical, diagnostic and basic research in HIV/TB. The Argentine/US Consortium is formed by the MSSM (within the Mount Sinai/New York University Health System), the State University of New York at Albany, the AIDS Institute of the NYS DOH with the Universidad Nacional de Buenos Aires, Hospital Clinicas, Fundacion Huesped, Hospital Fernandez, Hospital Garraham and Hospital Paroissien, and the Universidad Nacional de Rosario (Santa Fe, Argentina).