METABOLIC DETERMINANTS OF HYPERTENSION

高血压是一个复杂的疾病过程，涉及许多病理生理变化。在本项目中，个人研究课题集中在代谢因素导致高血压患者血压调节异常的主题上。该小组的战略是监测高血压发展过程中的许多相关变量，目的是确定从采取干预措施（实验性的、遗传性的或临床的）到血压升高的整个过程。这些变量包括神经和内分泌因子、细胞事件以及分子和遗传特征的改变。来自四个部门（三个临床部门和一个基础科学部门）的五名主要研究人员已经加入研究这些变化。动物模型将包括小鼠、实验性高血压和转基因修饰）、狗和大鼠。此外，还将评估人类与肥胖相关的高血压。测量的具体变量包括：特定蛋白质的mRNA、酶活性、遗传关联、血管反应性、血压、激素水平、内皮衍生产物和脂肪酸水平。研究策略将利用三个核心单元中的两个（核心B，动物和核心C，化学）中描述的专业知识和设备。将通过行政核心（核心A）协调生物统计支助和科学管理。通过这些综合项目，将更好地了解高血压的起始因素。

Hypertension is a complex disease process involving many pathophysiological changes. In this program Project, the individual research topics focus on the theme that metabolic factors contribute to abnormal blood pressure regulation in hypertension. The strategy of the group is to monitor many relevant variables during the development of hypertension with the goal of defining the complete sequence of events from the introduction of an intervention (experimentally imposed, genetic or clinical_ to the resultant elevation in blood pressure. Among these variables are alterations in neural and endocrine factors, cellular events and molecular and genetic characteristics. Five principal investigators from four departments (three clinical and one basic science) have joined to study these changes. Animal models will include mice, experimental hypertension and transgenically modified), dogs and rats. Additionally, obesity-related hypertension in humans will be evaluated. Among the specific variables measured will be the following: mRNA for specific proteins, enzyme activities, genetic associations, vascular reactivity, blood pressure, hormonal levels, endothelium-derived products and fatty acid levels. Research strategies will utilize the professional expertise and equipment described in two of the three core units (Core B, Animal and Core C, Chemistry). Biostatistics support and scientific management will be coordinated through the Administrative Core (Core A). From these integrated projects, a better understanding of the initiating factors of hypertension will emerge.