CORE--ANIMAL HISTOPATHOLOGY

动物组织病理学核心设施的目标是为用户提供可靠、高质量和具有成本效益的组织学服务，并使研究人员能够获得委员会认证的兽医病理学家的服务，包括准备石蜡切片、组织化学染色、准备冰冻切片、尸检技术和组织病理学分析方面的咨询和培训，以及提供专门的设备供研究人员使用。核心由弗吉尼亚·戈德弗雷执导，DVM，博士，ACVP，教务顾问大卫·李博士。动物组织病理学核心支持大量 使用鼠标作为模型系统的中心成员。核心支持的研究重点包括：熊跃博士(癌症细胞生物学)对缺乏CDKI p18和p27的基因敲除小鼠的分析，以及Bemard Weissman博士(癌症遗传学)发现WT2肿瘤抑制基因。未来的核心计划包括通过与突变小鼠区域资源中心(MMRRC)的互动接触到另一位兽医病理学家，以及增加有限的免疫组织化学服务。

The goals of the Animal Histopathology Core facility are to provide users with reliable, high quality, and cost-effective histologic services and to give investigators access to a board-certified veterinary pathologist Services include preparation of paraffin sections, histochemical staining, preparation of cryostat frozen sections, consultation and training in necropsy techniques and histopathologic assays, and provision of specialized equipment for use by investigators. The Core is directed by Virginia Godfrey, DVM, Ph.D, ACVP and the Faculty Advisor is Dr. David Lee. The Animal Histopathology Core supports a large number of Center members who use the mouse as a model system. Highlights of research supported by the Core include: analysis of knockout mice lacking CDKIs p18 and p27 by Dr. Yue Xiong (Cancer Cell Biology) and discovery of WT2 tumor suppressor gene by Dr. Bemard Weissman (Cancer Genetics). Future plans for the Core include access to another veterinary pathologist through interaction with the Mutant Mouse Regional Resource Center (MMRRC) and addition of limited immunohistochemistry services.