Novel Chelant Design for Improving Cleaning Performance and Sustainability of Consumer Goods

新颖的螯合剂设计可提高消费品的清洁性能和可持续性

• 批准号: 2600236
• 金额: --
• 依托单位: Durham University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2600236
• 关键词: Novel; Chelant; Design; Improving; Cleaning

Chelants are a fundamental ingredient in cleaning products for providing strong detergency but existing materials do not meet all of the properties that are currently desired (e.g., strong performance, biodegradable, nil-phosphorus, non-hazardous). The need for innovation in the field of metal control has become crucial in recent years as P&G strive to replace the 'classic chelants' in Fabric Care formulations with other molecular materials that have improved environmental profiles. The 'green' chelants which are currently available provide modest performance benefits, and with some disadvantages relative to conventionally used materials such as EDTA.The student, Lucy Woods, will design and synthesise small molecules based on siderophores. They are chelating molecules that have evolved in nature to help organisms meet their needs for metal ions, in particular iron, which is essential to all life forms. The key factors enabling strong performance will be modelled and used to inform the molecular design. In approaching the molecular design, the aim will be to preserve those molecular properties that provide strong metal-binding, while removing the functional groups which are involved in the bacterial cell uptake mechanisms. The lead candidates will be synthesised and screened for performance in P&G formulations, correlating the performance with properties such as metal ion affinity and lipophilicity, ultimately building up a detailed structure-activity relationship. These principal tasks will be informed by complementary molecular modelling and analytical characterisation.Time on the project will be split between the University (designing and synthesising novel chelants) and P&G (applying the novel chelants in P&G performance methods).

螯合剂是清洁产品中用于提供强去污力的基本成分，但现有材料不能满足目前所需的所有性能（例如，性能强、可生物降解、无磷、无害）。近年来，随着宝洁公司努力用其他改善环境状况的分子材料取代织物护理配方中的“经典螯合剂”，金属控制领域的创新需求变得至关重要。目前可用的“绿色”螯合剂提供适度的性能益处，并且相对于常规使用的材料如EDTA具有一些缺点。学生Lucy Woods将设计和合成基于铁载体的小分子。它们是螯合分子，在自然界中进化，以帮助生物体满足对金属离子的需求，特别是铁，这是所有生命形式所必需的。实现强大性能的关键因素将被建模并用于通知分子设计。在接近分子设计时，目标将是保留提供强金属结合的那些分子性质，同时去除参与细菌细胞摄取机制的官能团。将合成并筛选主要候选物在宝洁配方中的性能，将性能与金属离子亲和力和亲脂性等特性相关联，最终建立详细的结构-活性关系。这些主要任务将通过互补的分子建模和分析表征得到信息。该项目的时间将在大学（设计和合成新型螯合剂）和宝洁公司（将新型螯合剂应用于宝洁公司的性能方法）之间分配。