Creating synthetic regulatory modules to drive cell and tissue specific expression

创建合成调控模块来驱动细胞和组织特异性表达

• 批准号: 2600256
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2600256
• 关键词: Creating; synthetic; regulatory; modules; drive

One of the most challenging technical problems for molecular biology is driving gene expression in a highly specific manner so that it is only expressed specific in cells or tissues. Although some systems exist for driving gene expression in broad tissue types, it can be very difficult to drive expression in rare or highly specific target cells. In this project, we will use molecular biology and machine learning approaches to identify the rules of tissue specific gene expression so that we can design synthetic regulatory elements that can drive expression in any cell type of interest.UKRI-BBSRC priority areas: Understanding the rules of life, applying machine learning and synthetic biology.

分子生物学最具挑战性的技术问题之一是以高度特异性的方式驱动基因表达，使其仅在细胞或组织中特异性表达。尽管存在一些系统用于驱动广泛组织类型中的基因表达，但驱动稀有或高度特异性靶细胞中的表达可能非常困难。在这个项目中，我们将使用分子生物学和机器学习的方法来识别组织特异性基因表达的规则，这样我们就可以设计出可以驱动任何感兴趣的细胞类型表达的合成调控元件。UKRI-BBSRC优先领域：了解生命规则，应用机器学习和合成生物学。