Substance Abuse Research--Medications Development Center

描述(由申请人提供)： 单是滥用可卡因，再加上对海洛因的依赖，就会对个人和社会产生重大影响。药物滥用研究中心小组、德克萨斯大学休斯顿大学健康科学中心精神病学系和德克萨斯大学加尔维斯顿分校成瘾研究中心致力于开发和筛选有效的药物疗法。 活动包括科学/行政监督，以及实施特定的临床前、人体实验室、CRC住院和治疗研究诊所门诊研究。这些主题包括药物筛选和开发，疾病过程中干预点的指定(持续v戒断)，以及单独和联合使用最佳药物的描述。研究和临床活动包括一个重要的跨学科培训部分。这些目标将通过下列四个组成部分项目来实现： 1.科学项目--可卡因/海洛因：药物治疗给药方案。 2.科学项目--筛选戒除可卡因和预防复发的药物。 3.科学计划--冲动、脑功能和药物滥用治疗。 4.科学项目--药物对口服可卡因强化行为的影响。

DESCRIPTION (provided by applicant): Cocaine abuse alone, and co-ocurring with heroin dependence, have substantial individual and societal consequences. The Substance Abuse Research Center group, Department of Psychiatry, University of Texas Health Science Center-Houston and the Center for Addiction Research, University of Texas Medical Branch-Galveston, are devoted to development and screening of effective pharmacotherapies. Activities include Scientific/Administrative oversight, and implementation of specific preclinical, human laboratory, CRC inpatient, and Treatment Research Clinic outpatient studies. The themes include medication screening and development, specification of intervention points in disease course (ongoing v abstinence), and delineation of optimal medications alone and in combination. The research and clinical activity include a substantial interdisciplinary training component. The aims will be accomplished through four component projects listed below: 1. Scientific Project-Cocaine/Heroin: Pharmacotherapy Dosing Regimens. 2. Scientific Project-Screening Medications for Cocaine Cessation and Relapse Prevention. 3. Scientific Project-lmpulsivity, Brain Function & Substance Abuse Treatment. 4. Scientific Project-Drug Effects on Oral cocaine-Reinforced Behavior.