Chronic Pelvic Pain: Genetics/Neural Immune Mechanisms

慢性盆腔疼痛：遗传学/神经免疫机制

• 批准号: 6993746
• 负责人: pamela stratton
• 金额: --
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6993746
• 关键词: autoimmune disorder; chronic pain; clinical research; comorbidity; disease /disorder etiology; endometriosis; endometrium; epidemiology; female; gene expression; hormone regulation /control mechanism; human data; human subject; human tissue; musculoskeletal system; neural information processing; neuroimmunomodulation; neuromuscular function; neuroregulation; patient oriented research; pelvis; sex hormones; stress; women' s health

Chronic pelvic pain associated with endometriosis is poorly understood. This study is an effort to better understand pelvic pain and identify novel medical approaches for understanding it and treating it. We will examine the relations among sex hormones, pain processing, immune system substances and pain related genes. We will also examine changes in levels of hormonal and immune substances in the blood, endometriosis lesions and normal endometrial tissue. Myofascial pain has been noted in women with endometriosis and chronic pelvic pain. We will study how the nerve, muscle and skeletal systems are involved in pelvic pain by performing an in depth pain assessment. Finally, stress plays an important role generating and perpetuating chronic pain. We will examine how the hormones related to the stress response may be altered in pelvic pain. Comorbidities of endometriosis including autoimmune and other disease states. We analyzed a survey of almost 4000 women with surgically diagnosed endometriosis conducted by the Endometriosis Association. Almost all responders had pain (99%), and many reported infertility (41%). In this cohort of women with endometriosis, hypothyroidism, fibromyalgia, chronic fatigue syndrome, autoimmune diseases, allergies, and asthma are all significantly more common than in women in the general U.S. population. In the next two years, we are going to analyze the remainder of the survey to examine the types of medical and surgical treatments these women have experienced and their effectiveness, as well as other co-morbidities.

与子宫内膜异位症相关的慢性盆腔疼痛知之甚少。这项研究旨在更好地了解骨盆疼痛，并确定了解和治疗骨盆疼痛的新医学方法。我们将研究性激素、疼痛处理、免疫系统物质和疼痛相关基因之间的关系。我们还将检查血液、子宫内膜异位症病变和正常子宫内膜组织中激素和免疫物质水平的变化。肌筋膜痛在患有子宫内膜异位症和慢性盆腔疼痛的妇女中已被注意到。我们将通过进行深入的疼痛评估来研究神经、肌肉和骨骼系统如何参与骨盆疼痛。最后，压力对慢性疼痛的产生和延续起着重要作用。我们将研究如何在骨盆疼痛中改变与应激反应相关的激素。 子宫内膜异位症的并存，包括自身免疫和其他疾病状态。 我们分析了由子宫内膜异位症协会对近4000名经手术诊断为子宫内膜异位症的女性进行的调查。几乎所有应答者都有疼痛(99%)，许多人报告不孕(41%)。在这组患有子宫内膜异位症的女性中，甲状腺功能减退症、纤维肌痛、慢性疲劳综合征、自身免疫性疾病、过敏和哮喘都比普通美国人口中的女性更常见。在接下来的两年里，我们将分析调查的剩余部分，以检查这些女性经历过的内科和外科治疗的类型及其有效性，以及其他并发症。