Monitoring sarcopenic obesity in the elderly

监测老年人的肌肉减少性肥胖

• 批准号: 7022653
• 负责人: JOSEPH J KEHAYIAS
• 金额: $ 19.75万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7022653
• 关键词: X ray; bioengineering /biomedical engineering; biomedical equipment development; body composition; clinical biomedical equipment; clinical research; computed axial tomography; computer program /software; diagnosis quality /standard; field study; human old age (65+); human subject; muscle disorders; muscle function; patient monitoring device; photon absorptiometry; portable biomedical equipment; sarcopenia

DESCRIPTION (provided by applicant): Obesity in the elderly can be masked by body composition changes that result in a net weight loss. Sarcopenia, the loss of muscle and function with age, is universal in the elderly. The reduced protein stores inherent in sarcopenia leave the elderly with decreased ability to cope with illness or injury. The combination of increased %fat and sarcopenia results in a body composition status described as "sarcopenic obesity". This condition cannot be assessed by anthropometry or other traditional indirect body composition methods. The purpose of the proposed research is to develop and test a portable and relatively inexpensive instrument (X-ray absorptiometer) for carrying out body composition analysis of soft tissue in the field. These measurements are important for providing an index of nutritional status of individuals and will be used to evaluate the benefits and risks of anabolic treatments, nutritional support and the management of obesity in children and adults. Being portable, inexpensive, and simple to use, the instrument will permit the evaluation of nutritional health status of individuals in their own environment. It will be particularly beneficial to those for whom access to hospitals is difficult or limited (e.g. elderly in nursing homes or assisted living) or in underdeveloped nations, where aggressive nutrition support programs are being evaluated. The design is based on single and dual energy X-ray absorptiometry (DXA), optimized for soft tissue. The instrument is a hand-held caliper with a collimated X-ray source and a detector. The use of a simple detector array will facilitate the positioning of the caliper. The instrument will be evaluated for both single and dual energy mode and will be tested against mid-thigh CT and reference whole body composition techniques. The outcome of this research will be a fully developed and tested instrument and a method for its use in the field. This portable instrument will be particularly useful for monitoring sarcopenic obesity in the elderly where existing simple methods (such as Body Mass Index) fail to identify the true level of adipose tissue and frailty.

描述（由申请人提供）： 老年人的肥胖可以被身体成分的变化所掩盖，从而导致净体重减轻。肌肉减少症，即随着年龄增长而失去肌肉和功能，在老年人中是普遍的。肌肉减少症中固有的蛋白质储存减少使老年人科普疾病或伤害的能力下降。脂肪百分比增加和肌肉减少症相结合，导致被描述为“肌肉减少性肥胖”的身体成分状态。这种情况不能通过人体测量或其他传统的间接身体组成方法进行评估。 拟议研究的目的是开发和测试一种便携式和相对便宜的仪器（X射线吸收仪），用于在现场进行软组织的身体成分分析。这些测量对于提供个体营养状况的指数非常重要，并将用于评估儿童和成人合成代谢治疗，营养支持和肥胖管理的益处和风险。该仪器便携、廉价、使用简单，可用于评估个人在其自身环境中的营养健康状况。对于那些难以或有限进入医院的人（例如养老院或辅助生活的老年人）或正在评估积极营养支持计划的不发达国家，这将特别有益。该设计基于单能和双能X线吸收法（DXA），针对软组织进行了优化。该仪器是一种手持卡尺，具有准直X射线源和检测器。使用简单的探测器阵列将有助于卡尺的定位。将针对单能量和双能量模式对仪器进行评价，并将根据大腿中部CT和参考全身成分技术进行测试。这项研究的成果将是一个充分开发和测试的仪器和方法，在外地使用。这种便携式仪器将特别适用于监测老年人的肌肉减少性肥胖，现有的简单方法（如体重指数）无法识别脂肪组织和虚弱的真实水平。