Asian Teens, substance dependence and conduct disorder

亚洲青少年、物质依赖和行为障碍

• 批准号: 6949610
• 负责人: JOSEPH T SAKAI
• 金额: $ 17.84万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6949610
• 关键词: Asian Americans; adolescence (12-20); alcoholism /alcohol abuse; aldehyde dehydrogenases; alleles; behavioral /social science research tag; behavioral genetics; clinical research; conduct disorder; cytochrome P450; drug metabolism; enzyme activity; family genetics; genetic polymorphism; genetic susceptibility; genotype; human genetic material tag; human population study; human subject; interview; pharmacogenetics; social behavior disorders; substance abuse related behavior; substance abuse related disorder; tobacco abuse

DESCRIPTION (provided by applicant): This application proposes five years of support to investigate the relationship between substance dependence, conduct disorder and certain genetic polymorphisms among Asian American adolescents. There is little research characterizing conduct disordered Asian American adolescents. General population estimates and the applicant's preliminary data suggest conduct disordered Asian American adolescents are a high-risk population for comorbid substance use disorders. Asians also have high prevalence of alleles that are known to affect alcohol and nicotine metabolism. Therefore, conduct disordered Asian American adolescents likely represent a genetically informative population regarding adolescent substance use disorders. The applicant proposes to collect a sample of Asian American adolescents with conduct disorder (n=100), Asian adolescent controls (n=200), and first-degree relatives of conduct disordered probands (n=162). The aims include 1) examining the relationship between conduct disorder and substance use disorders among Asian American adolescents, 2) testing whether substance dependence and conduct disorder are familial in Asian American families, and 3) testing whether ALDH and CYP2A6 genotypes are associated with alcohol and nicotine dependence. The proposed training includes 1) completion of formal coursework and workshops dealing with twin studies, genetic association and linkage studies, 2) mentored analyses of data already collected (DA11015), focusing on within and between family genetic association studies of adolescent substance use disorders, 3) mentored analyses of national data bases examining risk factors for substance dependence among Asian Americans, and 4) attendance at national meetings.

描述（由申请人提供）： 该应用提出了五年的支持，以研究亚裔美国青少年中物质依赖，行为障碍和某些遗传多态性之间的关系。表征亚裔美国青少年行为无序的研究很少。一般人群估计和申请人的初步数据表明，亚裔美国青少年的行为无关，是合并药物使用障碍的高风险人群。亚洲人也患有高等位基因的流行率，这些等位基因已知会影响酒精和尼古丁代谢。因此，行为无序的亚裔美国青少年可能代表了有关青少年物质使用障碍的遗传信息人群。申请人建议收集具有行为障碍的亚裔美国青少年（n = 100），亚裔青少年对照（n = 200）和行为无序概率的一级亲属（n = 162）。目的包括1）检查亚裔美国青少年的行为障碍与物质使用障碍之间的关系，2）测试亚裔美国人家庭中的物质依赖和行为障碍是否是家族性的，3）测试ALDH和CYP2A6基因型是否与酒精和尼古丁依赖性有关。拟议的培训包括1）完成有关双研究研究的正式课程和研讨会，遗传关联和联系研究，2）对已经收集的数据的指导分析（DA11015）（DA11015），重点介绍了在青少年遗传性吸毒障碍的家庭遗传关联研究之间以及在国家 /地区的良好依赖性依赖性的国家数据基础上的良好数据基础的良好数据基础，以及4个属于美国人的依赖性。