Asian Teens, substance dependence and conduct disorder

描述（由申请人提供）： 该申请提出五年的支持，以调查亚裔美国青少年的物质依赖、品行障碍和某些遗传多态性之间的关系。很少有研究描述行为障碍的亚裔美国青少年。一般人口估计和申请人的初步数据表明，行为障碍的亚裔美国青少年是共病物质使用障碍的高风险人群。亚洲人的等位基因也很普遍，这些基因会影响酒精和尼古丁的代谢。因此，行为障碍的亚裔美国青少年可能代表了有关青少年药物使用障碍的遗传信息人群。申请人建议收集患有品行障碍的亚裔美国青少年（n=100）、亚裔青少年对照组（n=200）以及品行障碍先证者的一级亲属（n=162）的样本。目的包括 1) 检查亚裔美国青少年中品行障碍和物质使用障碍之间的关系，2) 测试物质依赖和品行障碍是否在亚裔美国家庭中具有家族性，以及 3) 测试 ALDH 和 CYP2A6 基因型是否与酒精和尼古丁依赖相关。拟议的培训包括 1) 完成涉及双胞胎研究、遗传关联和连锁研究的正式课程和研讨会，2) 对已收集的数据 (DA11015) 进行指导分析，重点是青少年药物使用障碍的家庭内部和家庭遗传关联研究，3) 对检查亚裔美国人物质依赖风险因素的国家数据库进行指导分析，以及 4) 参加全国会议。

DESCRIPTION (provided by applicant): This application proposes five years of support to investigate the relationship between substance dependence, conduct disorder and certain genetic polymorphisms among Asian American adolescents. There is little research characterizing conduct disordered Asian American adolescents. General population estimates and the applicant's preliminary data suggest conduct disordered Asian American adolescents are a high-risk population for comorbid substance use disorders. Asians also have high prevalence of alleles that are known to affect alcohol and nicotine metabolism. Therefore, conduct disordered Asian American adolescents likely represent a genetically informative population regarding adolescent substance use disorders. The applicant proposes to collect a sample of Asian American adolescents with conduct disorder (n=100), Asian adolescent controls (n=200), and first-degree relatives of conduct disordered probands (n=162). The aims include 1) examining the relationship between conduct disorder and substance use disorders among Asian American adolescents, 2) testing whether substance dependence and conduct disorder are familial in Asian American families, and 3) testing whether ALDH and CYP2A6 genotypes are associated with alcohol and nicotine dependence. The proposed training includes 1) completion of formal coursework and workshops dealing with twin studies, genetic association and linkage studies, 2) mentored analyses of data already collected (DA11015), focusing on within and between family genetic association studies of adolescent substance use disorders, 3) mentored analyses of national data bases examining risk factors for substance dependence among Asian Americans, and 4) attendance at national meetings.