Asian Teens, substance dependence and conduct disorder

描述(由申请人提供)： 这项申请提出了为期五年的支持，以调查亚裔美国青少年中物质依赖、行为障碍和某些基因多态之间的关系。很少有研究以亚裔美国青少年的行为障碍为特征。总体人口估计和申请者的初步数据表明，品行障碍的亚裔美国青少年是共病物质使用障碍的高危人群。亚洲人也有很高的等位基因，已知这些等位基因会影响酒精和尼古丁代谢。因此，行为障碍的亚裔美国青少年很可能代表了关于青少年物质使用障碍的遗传信息人群。申请人建议收集有品行障碍的亚裔美国青少年(n=100)、对照亚裔青少年(n=200)和行为障碍先证者的一级亲属(n=162)的样本。研究目的包括：1)研究亚裔美国青少年的品行障碍与物质使用障碍之间的关系；2)检测物质依赖和品行障碍在亚裔美国人家庭中是否有家族遗传；3)检测ALDH和CYP2A6基因是否与酒精和尼古丁依赖有关。拟议的培训包括1)完成关于双胞胎研究、遗传关联和连锁研究的正式课程和讲习班，2)对已收集的数据进行有指导的分析(DA11015)，重点是青少年药物使用障碍的家庭内和家庭之间的遗传关联研究，3)对审查亚裔美国人物质依赖风险因素的国家数据库进行有指导的分析，以及4)出席国家会议。

DESCRIPTION (provided by applicant): This application proposes five years of support to investigate the relationship between substance dependence, conduct disorder and certain genetic polymorphisms among Asian American adolescents. There is little research characterizing conduct disordered Asian American adolescents. General population estimates and the applicant's preliminary data suggest conduct disordered Asian American adolescents are a high-risk population for comorbid substance use disorders. Asians also have high prevalence of alleles that are known to affect alcohol and nicotine metabolism. Therefore, conduct disordered Asian American adolescents likely represent a genetically informative population regarding adolescent substance use disorders. The applicant proposes to collect a sample of Asian American adolescents with conduct disorder (n=100), Asian adolescent controls (n=200), and first-degree relatives of conduct disordered probands (n=162). The aims include 1) examining the relationship between conduct disorder and substance use disorders among Asian American adolescents, 2) testing whether substance dependence and conduct disorder are familial in Asian American families, and 3) testing whether ALDH and CYP2A6 genotypes are associated with alcohol and nicotine dependence. The proposed training includes 1) completion of formal coursework and workshops dealing with twin studies, genetic association and linkage studies, 2) mentored analyses of data already collected (DA11015), focusing on within and between family genetic association studies of adolescent substance use disorders, 3) mentored analyses of national data bases examining risk factors for substance dependence among Asian Americans, and 4) attendance at national meetings.