Regulation of Fibroblast Survival in the Collagen Matrix
Regulation of Fibroblast Survival in the Collagen Matrix
批准号:
6949030
负责人:
MARK A CARLSON
金额:
$11.35万
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-09-30 至 2006-09-29
关键词:
actinsapoptosisbiological signal transductioncell growth regulationcollagencysteine endopeptidasesenzyme activityextracellular matrixfibroblastsfocal adhesion kinasehuman tissueimmunocytochemistryintegrinsintermolecular interactionlaboratory mousep53 gene /proteinphosphatidylinositol 3 kinasephosphorylationprotein structure functionskinterminal nick end labelingtranscription factorwestern blottingswound healing
中文摘要
描述(由申请人提供):候选人正在寻求职业生涯
英文摘要
DESCRIPTION (provided by applicant): The candidate is pursuing a career in
academic surgery as an Assistant Professor of Surgery at the University of
Nebraska Medical Center. His clinical interests include minimally invasive and
robotic surgery and surgery of the abdominal wall His basic science interests
include the regulation of wound healing, granulation tissue regression, and
tissue regeneration. He has completed a 6 year residency in general surgery
(Medical College of Wisconsin), a 1 year fellowship in minimally invasive
surgery (MCW), and a 3 year fellowship in basic research (wound healing) with
Fred Giinnell at the University of Texas Southwestern Medical Center. His
short-term goal is to establish, with the help of extramural funding, a career
in academic surgery at UNMC. His long-term goals include a greater
understanding of the healing mechanism, progress towards achieving tissue
regeneration, and advancement of minimally invasive and robotic surgery.
The UNMC Surgery Chairman hired the candidate with the intent that the
candidate would concentrate 75 percent of his efforts on research and career
development. The candidate?s career development plan involves a combination of
basic science research, didactic lectures, seminars, specialty courses,
scientific meetings, research presentations, and scholarly debate/discussions.
The candidate has 3 sponsors: a senior academic surgeon, a surgeon who is an
established wound healing investigator, and a cell biologist experienced in
apoptotic signal transduction. The latter two sponsors have NIH-funded
laboratories. The candidate foresees a 4 year period to perform the proposed
experiments and prepare an R01 application.
The candidate's research plan will investigate the regulation of fibroblast
survival in the collagen matrix. The clinical relevance is that since the
fibroblast is the primary cell involved with complications/untoward effects of
healing and scarring, control over fibroblast survival during healing should
allow the clinician to minimize the negative effects of scarring in select
clinical circumstances, such as in burn wound contracture, GI anastomotic
stricture, or cirrhosis. The candidate has hypothesized that matrix anchorage
upregulates focal adhesion kinase activity, which in turn upregulates the
PI3K/Akt survival pathway and inhibits the tumor suppressor p53, ultimately
promoting cell survival. Loss of matrix anchorage is hypothesized to reverse
these effects and induce apoptosis. The involvement of each protein will be
probed with mutated isoforms.
期刊论文(12)
专著(0)
科研奖励(0)
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MCPIP1 Regulates Fibroblast Migration in 3-D Collagen Matrices Downstream of MAP Kinases and NF-κB.
MCPIP1 调节 MAP 激酶和 NF-kappaB 下游 3-D 胶原基质中成纤维细胞的迁移。
DOI:
10.1038/jid.2015.334
发表时间:
2015-12
期刊:
The Journal of investigative dermatology
影响因子:
--
作者:
[Chao J, Dai X, Peña T, Doyle DA, Guenther TM, Carlson MA]
通讯作者:
Carlson MA
Minimally invasive ventral herniorrhaphy: an analysis of 6,266 published cases.
微创腹侧疝修补术:对 6,266 例已发表病例的分析。
DOI:
10.1007/s10029-007-0286-4
发表时间:
2008
期刊:
Hernia : the journal of hernias and abdominal wall surgery
影响因子:
--
作者:
[Carlson,MA, Frantzides,CT, Shostrom,VK, Laguna,LE]
通讯作者:
Laguna,LE
Laparoscopic revision of failed fundoplication and hiatal herniorraphy.
失败的胃底折叠术和食管裂孔疝修补术的腹腔镜翻修术。
DOI:
10.1089/lap.2008.0245
发表时间:
2009
期刊:
Journal of laparoendoscopic & advanced surgical techniques. Part A
影响因子:
--
作者:
[Frantzides,ConstantineT, Madan,AtulK, Carlson,MarkA, Zeni,TallalM, Zografakis,JohnG, Moore,RonaldM, Meiselman,Mick, Luu,Minh, Ayiomamitis,GeorgiosD]
通讯作者:
Ayiomamitis,GeorgiosD
Minimally invasive incisional herniorrhaphy: a review of 208 cases.
微创切口疝修补术:208 例回顾。
DOI:
10.1007/s00464-004-8105-9
发表时间:
2004
期刊:
Surgical endoscopy
影响因子:
--
作者:
[Frantzides,CT, Carlson,MA, Zografakis,JG, Madan,AK, Moore,RE]
通讯作者:
Moore,RE
DOI:
10.1016/j.jss.2003.12.002
发表时间:
2004-08
期刊:
The Journal of surgical research
影响因子:
--
作者:
[M. A. Carlson;M. Longaker;Jon S Thompson]
通讯作者:
M. A. Carlson;M. Longaker;Jon S Thompson
共 6 条
Effect of cell-based therapies on functional, hemodynamic, and histologic outcomes in a porcine model of peripheral arterial disease
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批准号:10609836
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财政年份:2019
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负责人:MARK A CARLSON
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依托单位:
Effect of cell-based therapies on functional, hemodynamic, and histologic outcomes in a porcine model of peripheral arterial disease
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批准号:10371217
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Development and Application of a Porcine Model of Pancreatic Cancer
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批准号:9891972
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项目类别:
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资助金额:$63.0万
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财政年份:2018
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负责人:MARK A CARLSON
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依托单位:
Regulation of Fibroblast Survival in the Collagen Matrix
-
批准号:6382569
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项目类别:
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资助金额:$10.62万
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财政年份:2001
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负责人:MARK A CARLSON
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依托单位:
Regulation of Fibroblast Survival in the Collagen Matrix
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批准号:6525384
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项目类别:
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资助金额:$10.39万
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财政年份:2001
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负责人:MARK A CARLSON
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依托单位:
Regulation of Fibroblast Survival in the Collagen Matrix
-
批准号:6649330
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项目类别:
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资助金额:$10.7万
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财政年份:2001
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负责人:MARK A CARLSON
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依托单位:
Regulation of Fibroblast Survival in the Collagen Matrix
-
批准号:6800063
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项目类别:
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资助金额:$11.02万
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财政年份:2001
-
负责人:MARK A CARLSON
-
依托单位:
国内基金
海外基金
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