Center for Cancer Research Development

癌症研究发展中心

• 批准号: 6798776
• 负责人: Douglas Carter Hixson
• 金额: $ 160.72万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6798776
• 关键词: clinical research; health science research potential; neoplasm /cancer

DESCRIPTION (provided by applicant): The mission of the Center for Cancer Research Development is to coalesce and foster outstanding, interactive, laboratory-based cancer research centered on the Molecular and Cellular Pathogenesis of Cancer. To this end, three program projects, each with two subprojects will be initiated in year one along with four pilot projects, the latter supported by funds from Rhode Island Hospital/Academic Medical Center (RIH/AMC). The goal will be to develop program projects in four different but related themes, into interactive research groups composed of at least 3 junior investigators supported by peer reviewed grants. This will be accomplished by establishing and perpetuating an intellectually dynamic training environment in which junior investigators will create and disseminate new knowledge and clinical applications and with the guidance of senior faculty mentors, build nationally competitive, independent, but interactive research programs. The investigators will utilize common model systems and state-of-the-art core facilities in administration, career development, proteomics and molecular pathology to 1) discover mechanisms leading to neoplasia and 2) develop clinical applications resulting from this knowledge. The six subprojects, mentored by a team of seven senior faculty including the PI and Co-PI, target programmatic themes in gastrointestinal cancer, developmental proteins and intracellular signaling pathways. A fourth theme in viral mechanisms of carcinogenesis is represented by pilot projects funded by the institution. The proposal represents a strategic partnership in which RIH/AMC will commit significant resources to supplement those requested in this application to build cohesive strength in basic cancer research that complements existing strengths in clinical cancer treatment, outreach, and prevention. The long-term goal of this support is to achieve NCI designation as a Comprehensive Cancer Center. Guidance for the Center will be provided by teams of Internal and External Advisors and Consultants including a Translational Research Group together with a carefully considered plan of training, evaluation and succession. The end result will be a Cancer Research Center of investigators with significant programmatic strengths and translational impact.

描述（由申请人提供）：癌症研究发展中心的使命是联合和促进以癌症的分子和细胞发病机制为中心的杰出的、互动的、基于实验室的癌症研究。为此，第一年将启动三个方案项目，每个项目有两个子项目，沿着四个试点项目，后者由罗得岛医院/学术医疗中心（RIH/AMC）资助。我们的目标是在四个不同但相关的主题中开发项目，进入由至少3名初级研究人员组成的互动研究小组，由同行评审的赠款支持。 这将通过建立和保持一个智力动态的培训环境来实现，在这个环境中，初级研究人员将创造和传播新知识和临床应用，并在高级教师导师的指导下，建立具有国家竞争力，独立但互动的研究项目。研究人员将利用管理、职业发展、蛋白质组学和分子病理学方面的通用模型系统和最先进的核心设施，1）发现导致肿瘤形成的机制，2）开发这些知识的临床应用。这六个子项目由包括PI和Co-PI在内的七名高级教师组成的团队指导，目标是胃肠道癌症，发育蛋白质和细胞内信号通路的方案主题。病毒致癌机制的第四个主题是由该机构资助的试点项目。该提案代表了一种战略伙伴关系，RIH/AMC将投入大量资源，以补充本申请中要求的资源，从而在基础癌症研究中建立凝聚力，补充临床癌症治疗，外展和预防方面的现有优势。这种支持的长期目标是实现NCI指定为综合癌症中心。中心的指导将由内部和外部顾问和顾问团队提供，包括翻译研究小组以及经过仔细考虑的培训，评估和继任计划。最终的结果将是一个癌症研究中心的研究人员具有显着的程序优势和翻译的影响。