Export of effector proteins by P. falciparum to the infected erythrocyte.

恶性疟原虫将效应蛋白输出至受感染的红细胞。

• 批准号: nhmrc : 1037643
• 负责人: Dr Neta Regev-Rudzki
• 金额: $ 13.11万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/export-effector-proteins-infected-erythrocyte/111090
• 关键词: Export; effector; proteins; P.; falciparum

Infection by the malaria parasite has lethal consequences for humans. In order to survive the parasite exports hundreds of proteins to commandeer the erythrocyte. A translocon that mediates such export has been identified and important questions remain unanswered. In this research, I aim to determine the function of one of the major translocon components for export of proteins to the erythrocyte (EXP2) and through this process determine if it is a viable target for anti-malarial drug development.

疟疾寄生虫的感染对人类有致命的后果。为了生存，寄生虫会输出数百种蛋白质来占领红细胞。已经确定了一种介导这种出口的易位子，重要的问题仍然没有答案。在这项研究中，我的目标是确定蛋白质输出到红细胞（EXP2）的主要易位子组件之一的功能，并通过这个过程确定它是否是抗疟疾药物开发的可行目标。