From the bee's knees to biotechnology: Resilin-based hydrogels for cell-culture and bioprinting

从蜜蜂膝盖到生物技术：用于细胞培养和生物打印的基于 Resilin 的水凝胶

• 批准号: 2606691
• 金额: --
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2606691
• 关键词: bee; knees; biotechnology; Resilin; based

Hydrogels belong to the most promising materials for cell-culture and tissue engineering. While biocompatibility and degradability of hydrogels are vital for use in cell-culture, mechanical properties have a significant impact on the cell differentiation. Therefore, hydrogel systems with well-controlled and tailorable mechanical properties are highly sought after. The present project will investigate the use of resilin in hydrogel fabrication as an environment for cell-growth with the ultimate goal of tissue engineering. Resilin has remarkable properties (as an elastomer it is literally the bee's knees), which facilitates the introduction of a broad range of mechanical properties together with crosslinking chemistry, e.g. via carbon nitride in the visible light. Moreover, the project will make use of a modular approach to introduce further functions into the hydrogels in order to enhance cell-growth. Overall, the project will give rise to new robust 'tuneable' gels that will address many of the shortcomings of existing cell culture media and will represent realistic alternatives to animal derived materials in research.

水凝胶是细胞培养和组织工程中最有前途的材料。尽管水凝胶的生物相容性和可降解性对细胞培养至关重要，但机械性能对细胞分化有重要影响。因此，具有良好控制和可剪裁的力学性能的水凝胶体系备受追捧。本项目将研究Resilin在水凝胶制造中作为细胞生长环境的使用，最终目标是组织工程。Resilin具有显著的性能(作为一种弹性体，其字面意思就是蜜蜂的膝盖)，这有助于引入广泛的机械性能以及交联化学，例如通过可见光下的氮化碳。此外，该项目将利用模块化方法在水凝胶中引入更多功能，以促进细胞生长。总体而言，该项目将产生新的强大的“可调”凝胶，将解决现有细胞培养介质的许多缺点，并将在研究中代表现实的动物来源材料的替代方案。