Evaluate and design anti-viral actives

点击翻译按钮获取中文摘要

Viruses present in a broad range of shapes and sizes, but are much smaller than bacteria. The notorious ones, including influenza, rotavirus, norovirus, respiratory syncytial virus, and of course coronavirus, are enveloped by lipid membrane, which could be disrupted by amphiphilic actives, in either bulk liquid or at solid/liquid interface. The chemical industry needs to work with virologists in addressing critical questions such as, which actives should be used? What are the action mechanisms? At what concentration? Under which conditions? We aim to develop effective anti-viral compounds that can intervene and inactivate viruses at various stages of transmission. Several levers have been identified to inhibit virus transmission. From anti-viral compounds point of view, it requires a coherent programme linking molecular architecture design to lab validation, using colloidal science, formulation engineering, and viral testing capability.