Age Differences in Ethanol Effects: Tolerance and Reward

乙醇影响的年龄差异：耐受性和奖励

• 批准号: 7057500
• 负责人: ROBERT C RISTUCCIA
• 金额: $ 3.04万
• 依托单位: STATE UNIVERSITY OF NY,BINGHAMTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7057500
• 关键词: adolescence (12-20); age difference; alcoholic beverage consumption; autonomic nervous system; biomarker; brain electrical activity; dopamine; drug tolerance; ethanol; laboratory rat; neuropsychology; neurotoxicology; neurotransmitter transport; predoctoral investigator; reinforcer; substance abuse epidemiology

DESCRIPTION (provided by applicant): While the exact cause of the increase in ethanol consumption during adolescence is not known, age differences in tolerance development and sensitivity to ethanol's rewarding effect may play a contributory role. The proposed research will examine age differences in tolerance to ethanol's effects on the autonomic system as well as several potential markers of ethanol's hedonic effects between adolescent and adult rats. Using a 2-hour limited access paradigm, tolerance to ethanol's autonomic effects as well as the effects of ethanol on markers of dopamine functioning within brain pathways implicated in reward will be measured in animals of both ages. This testing paradigm will provide a unique assessment of age differences in these factors as previous work in this area has used experimenter-administered ethanol but work in our laboratory has indicated that mode of ethanol administration may differentially impact adolescents and adults. Adolescents are expected to show less acute sensitivity to ethanol, faster tolerance development and less dopaminergic activity following chronic ethanol exposure than adults, supporting the hypothesis that younger animals consume more ethanol than adults in part because of their relative insensitivity to its effects.

描述（由申请人提供）：虽然青春期乙醇消耗量增加的确切原因尚不清楚，但耐受性发育和对乙醇奖励效应的敏感性的年龄差异可能起一定作用。拟议的研究将检查乙醇对自主神经系统影响的耐受性的年龄差异