BSL-3 Emerging Pathogens Research Facility

描述(由申请人提供)： 该项目是佛罗里达大学动物研究基础设施扩建、改善和现代化的十年总体计划的一部分。认识到咖啡馆主要需要翻新，以纠正暖通空调的缺陷、过时的设计和包括空间不足在内的其他缺陷，在教职员工和管理人员的参与下，制定了一个三阶段计划。第一阶段已完成，并为新的暖通空调供电系统提供了冗余。第二阶段将在现有的CAF设施上增加一座62,975 GSF建筑，设计为SPF屏障并指定为附件。第二阶段的部分资金由国立卫生研究院提供，其余部分由该大学提供。这一阶段正处于规划阶段。第三阶段有两个部分，将对现有的CAF进行重新配置和现代化，并取代破旧的暖通空调系统的其余部分。第三阶段的第一部分是本提案的主题，将对CAF的ABSL3套房进行重新配置、现代化改造和扩建，以提供BSL3实验室和ABSL3动物室和支持空间。第三阶段第二部分将对CAF设施的其余部分进行重新配置和现代化，包括更换其余破旧的暖通空调系统。目前有120多名调查人员使用该咖啡馆。其中，14名调查人员有22个正在进行的项目。所有这些项目都支持NIAID生物防御和新发传染病议程，并将使用BRF来安置他们的研究动物。此外，目前获得资助的29个项目的11名调查员需要BSL3/ABSL3设施来完成他们的工作，也将从这一拟议项目中受益。 该提案要求提供部分资金，用于重新配置和扩大现有的CAF ABSL3套间，以创建一个BSL3研究设施(第三阶段的第一部分)。最先进的设施将把为套房提供服务的暖通空调升级到现代的ABSL3标准，并采用在套房屏障内提供适当的实验室、支撑和动物住所空间的设计。支持空间将包括成像、流式细胞仪和气溶胶挑战套件。该项目将使J.Hillis Miller健康中心的BSL3实验室可用空间增加60%以上。增加的实验室空间中的三分之二将立即与一个动物室相关联，以支持实验室的功能。

DESCRIPTION (provided by applicant): This project is part of a 10-year master plan to expand, improve and modernize the University of Florida's animal research infrastructure. Recognizing that the CAF was in major need of renovations to correct HVAC deficiencies, outdated design, and other deficiencies including insufficient space, a three phase plan was devised with input from faculty and administration. Phase I is complete and provided new HVAC supply units with redundancy. Phase II will add a 62,975 gsf building, designed as a SPF barrier and designated the Annex, onto the existing CAF facility. Phase II is partially funded by the NIH with the remainder provided by the University. This phase is in the planning stage. Phase III has two parts and will reconfigure and modernize the existing CAF and replace the remainder of the worn out HVAC. Part I of Phase III is the subject of this proposal and will reconfigure, modernize and enlarge the ABSL3 suite in CAF to provide both BSL3 laboratories and ABSL3 animal rooms and support space. Part II of Phase III will reconfigure and modernize the remainder of the CAF facility including replacement of the remainder of the worn out HVAC. Over 120 Investigators currently use the CAF. Of these, 14 investigators have 22 active projects. All these projects support the NIAID biodefense and emerging infectious diseases agenda and will use the BRF to house their research animals. In addition, 11 investigators with 29 currently funded projects require BSL3/ABSL3 facilities to complete their work and would also benefit from this proposed project. This proposal requests partial funding for reconfiguration and enlargement of the existing CAF ABSL3 suite to create a BSL3 Research Facility (Part I of Phase III). The state of the art facility will upgrade the HVAC serving the suite to modern ABSL3 standards and incorporate a design that provides appropriate laboratory, support and animal housing space within the suite barrier. The support space will include imaging, flow cytometry and an aerosol challenge suite. This project will increase the available BSL3 laboratory space in the J. Hillis Miller Health Center by more than 60%. Two-thirds of the increased laboratory space will be will be immediately associated with an animal room to support the laboratory functions.