BSL-3 Emerging Pathogens Research Facility

描述（由申请人提供）： 该项目是一个10年总体规划的一部分，以扩大，改善和现代化的佛罗里达的动物研究基础设施的大学。认识到CAF是在主要需要装修，以纠正暖通空调的缺陷，过时的设计，和其他缺陷，包括空间不足，一个三阶段的计划设计与教师和行政部门的投入。第一阶段已经完成，并提供了新的暖通空调供应单位与冗余。第二阶段将在现有的CAF设施上增加一个62，975 gsf的建筑，设计为SPF屏障并指定为附件。第二阶段部分由NIH资助，其余部分由大学提供。这一阶段处于规划阶段。第三阶段有两个部分，将重新配置和现代化现有的CAF，并更换剩余的破旧的暖通空调。第三阶段的第一部分是本提案的主题，将重新配置，现代化和扩大CAF的ABSL 3套房，以提供BSL 3实验室和ABSL 3动物房和支持空间。第三阶段的第二部分将对CAF设施的剩余部分进行重新配置和现代化改造，包括更换剩余的破旧HVAC。目前有120多名调查员使用CAF。其中，14名调查员负责22个正在进行的项目。 所有这些项目都支持NIAID生物防御和新兴传染病议程，并将使用BRF来安置他们的研究动物。此外，目前有29个资助项目的11名调查员需要BSL 3/ABSL 3设施来完成他们的工作，他们也将从拟议的项目中受益。 该提案要求为现有CAF ABSL 3套件的重新配置和扩大提供部分资金，以创建BSL 3研究设施（第三阶段的第一部分）。最先进的设施将升级为现代ABSL 3标准的套房HVAC，并纳入在套房屏障内提供适当实验室、支持和动物饲养空间的设计。支持空间将包括成像，流式细胞术和气溶胶挑战套件。该项目将使希利斯米勒健康中心的BSL 3实验室空间增加60%以上。增加的实验室空间的三分之二将立即与动物房相关联，以支持实验室功能。

DESCRIPTION (provided by applicant): This project is part of a 10-year master plan to expand, improve and modernize the University of Florida's animal research infrastructure. Recognizing that the CAF was in major need of renovations to correct HVAC deficiencies, outdated design, and other deficiencies including insufficient space, a three phase plan was devised with input from faculty and administration. Phase I is complete and provided new HVAC supply units with redundancy. Phase II will add a 62,975 gsf building, designed as a SPF barrier and designated the Annex, onto the existing CAF facility. Phase II is partially funded by the NIH with the remainder provided by the University. This phase is in the planning stage. Phase III has two parts and will reconfigure and modernize the existing CAF and replace the remainder of the worn out HVAC. Part I of Phase III is the subject of this proposal and will reconfigure, modernize and enlarge the ABSL3 suite in CAF to provide both BSL3 laboratories and ABSL3 animal rooms and support space. Part II of Phase III will reconfigure and modernize the remainder of the CAF facility including replacement of the remainder of the worn out HVAC. Over 120 Investigators currently use the CAF. Of these, 14 investigators have 22 active projects. All these projects support the NIAID biodefense and emerging infectious diseases agenda and will use the BRF to house their research animals. In addition, 11 investigators with 29 currently funded projects require BSL3/ABSL3 facilities to complete their work and would also benefit from this proposed project. This proposal requests partial funding for reconfiguration and enlargement of the existing CAF ABSL3 suite to create a BSL3 Research Facility (Part I of Phase III). The state of the art facility will upgrade the HVAC serving the suite to modern ABSL3 standards and incorporate a design that provides appropriate laboratory, support and animal housing space within the suite barrier. The support space will include imaging, flow cytometry and an aerosol challenge suite. This project will increase the available BSL3 laboratory space in the J. Hillis Miller Health Center by more than 60%. Two-thirds of the increased laboratory space will be will be immediately associated with an animal room to support the laboratory functions.