Synthesis of Spiro-Azetidines via Photoinduced Strain Release of Azabicyclo

氮杂双环光诱导应变释放合成螺氮杂环丁烷

• 批准号: 2610894
• 金额: --
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2610894
• 关键词: Synthesis; Spiro; Azetidines; via; Photoinduced

This project falls within the EPSRC Synthetic Organic Chemistry research area.Spirocycles are privileged structures in medicinal chemistry due to their rigidity, high sp3 content and ease of access to unexplored three-dimensional chemical space. Spirocyclic molecules, and in particular spiroazetidines, have proved to be valuable bioisosteres for medicinally relevant groups such as morpholines and piperidines with metabolic stability and protein binding being improved significantly.

该项目属于EPSRC合成有机化学研究领域。螺旋环由于其刚性、高sp3含量和易于进入未开发的三维化学空间而成为药物化学中的特权结构。螺旋环分子，特别是螺旋氮杂啶，已被证明是有价值的生物异构体，用于医学相关的类群，如morpholines和胡椒碱，代谢稳定性和蛋白质结合得到显著改善。