The role of 5-HT receptor biased organism of psychedelic drug action

5-HT受体偏向生物体对致幻药物作用的作用

• 批准号: 2611527
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2611527
• 关键词: role; HT; receptor; biased; organism

Project based on the emerging pharmacological concept of biased agonism, applied to the 5-HT2A receptor in the context of psychedelic drugs and antidepressant action.Project focuses on the pharmacological actions of the psychedelic agent psilocin, which is a 5-HT agonist and the active molecule of psilocybin. A number of clinical trials have established efficacy of psilocybin in major depression and anxiety disorders.

该项目基于偏激动作用的新兴药理学概念，应用于迷幻药和抗抑郁作用背景下的5-HT 2A受体。项目重点是迷幻剂psilocin的药理作用，psilocin是一种5-HT激动剂和psilocybin的活性分子。许多临床试验已经确定了裸盖菇素在重度抑郁症和焦虑症中的疗效。