CORE B--CLINICAL/BIOSTATISTICS

描述(由申请人提供)： 临床/生物统计学核心的功能： 1)DNA和其他样本的采购、组织和分发 特点明确的主题，为特定的SCOR项目服务；招聘 个人为特定的SCOR项目提供血浆和血细胞。 2)在SCOR方案中提供生物数学和生物统计分析； 包括遗传数据的统计分析、数据处理和管理 和数学建模。 核心的一个主要目标是确保DNA和血液样本受试者的安全 分析以确定基因和分子对动脉粥样硬化形成的贡献。 此核心将填补SCOR计划所需的关键角色 分子医学和动脉粥样硬化，即它将提供临床 供个体研究的资源(DNA、巨噬细胞和血浆样本) 项目，允许整合基础和临床资源。此外， CORE将促进调查人员、项目和核心之间的合作 在哥伦比亚大学SCOR计划内，额外的外部资源和 其他动脉粥样硬化SCOR计划。

DESCRIPTION (provided by the applicant): Function of the Clinical/Biostatistics Core: 1) Procurement, organization, and distribution of DNA and other samples from well characterized subjects, to service specific SCOR projects; recruitment of individuals to provide plasma and blood cells for specific SCOR projects. 2) Provision of biomathematics and biostatistics analyses in the SCOR program, including statistical analysis of genetic data, data processing and management and mathematical modeling. A major goal of the Core is to secure the DNA and blood samples subjects and analyses to define the genetic and molecular contributions to atherogenesis. This Core will fill a critical role that is required of the SCOR program in Molecular Medicine and Atherosclerosis, i.e. it will provide clinical resources (DNA, macrophages, and plasma samples) for study in the individual projects, allowing integration of basic and clinical resources. Further, the Core will facilitate collaboration among investigators, projects and cores within the Columbia University SCOR program, additional outside resources and other atherosclerosis SCOR programs.