Core--Ascertainment and Clinical

核心——确定和临床

• 批准号: 6812939
• 负责人: William K SCOTT
• 金额: $ 47.63万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6812939
• 关键词: Parkinson' s disease; biomedical facility; brain disorder diagnosis; clinical research; data collection; family genetics; genetic susceptibility; human genetic material tag; human subject; medical outreach /case finding; postmortem; sample collection; tissue resource /registry

Continuing scientific progress in Parkinson's disease (PD) and other parkinsonian syndromes relies upon accurate diagnosis of these disorders and the availability of patients and controls for study. The Ascertainment and Clinical Core of the Duke Udall Parkinson's Disease Research Center of Excellence ("Duke Udall PDRCE") builds on the diagnostic and family ascertainment expertise of the Duke Center for Human Genetics. While the main goal of the core is to provide diagnostic expertise and facilitate the genetic family studies and other multidisciplinary efforts of Duke Udall PDRCE projects, the clinical data, DNA samples and tissue bank resources developed by the core will benefit other independently funded investigations of PD as well. There are three specific aims of the Ascertainment and Clinical Core: 1. Enroll 200 families in genetic studies of PD. 2. Maintain an active autopsy and tissue donation program. 3. Collect and database detailed clinical, family history, and environmental risk factor data on all participants.

帕金森氏病(PD)和其他帕金森综合征的持续科学进步依赖于对这些疾病的准确诊断以及患者和对照研究的可用性。杜克大学尤德尔帕金森病卓越研究中心(“杜克大学帕金森氏病研究中心”)的确定和临床核心建立在杜克大学人类遗传学中心的诊断和家族确定专业知识的基础上。虽然CORE的主要目标是提供诊断专业知识，并促进杜克大学Udall PDRCE项目的基因家系研究和其他多学科努力，但CORE开发的临床数据、DNA样本和组织库资源也将有利于其他独立资助的帕金森病研究。《确定和临床核心》有三个具体目标： 1.招募200个家系参与帕金森病的遗传学研究。 2.维持积极的尸检和组织捐赠计划。 3.收集所有患者的详细临床、家族史和环境风险因素数据并将其存入数据库 参与者。