A Genomic Study of Sex-Role and Social Dominance

性别角色和社会主导地位的基因组研究

• 批准号: 6846850
• 负责人: SUSAN C.P. RENN
• 金额: $ 5.35万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6846850
• 关键词: behavioral /social science research tag; behavioral genetics; brain; evolution; gene expression; genome; microarray technology; neurogenetics; phenotype; polymerase chain reaction; postdoctoral investigator; sex behavior; social dominance; zebrafish

DESCRIPTION (provided by applicant): The goal of this project is to identify genetic mechanisms in the brain that underlie different sexual behaviors. Through the combined use of the genetic model zebrafish and the evolutionarily fascinating African cichlid fishes, this project will address the genetic basis of behavior in the context of evolution by determining to what extent the genetic mechanisms of different sexual behaviors in different species have arisen through conserved or convergent evolution. I will identify sex-specific genes in the adult and larval brain using zebrafish to take advantage of the functional annotations of the genome and apply the full force of bioinformatics techniques. This information will allow me to expand the breadth of experimentation and analysis for the study of sex-role behavior and dominance in the cichlids. In addition to evolutionary implications, these studies will inform further hypotheses to be tested through functional analysis.

描述(由申请者提供)：这个项目的目标是确定大脑中不同性行为背后的遗传机制。通过结合使用遗传模型斑马鱼和进化上令人着迷的非洲卷尾鱼，该项目将通过确定不同物种中不同性行为的遗传机制在多大程度上通过保守或收敛进化来解决进化背景下行为的遗传基础。我将使用斑马鱼识别成虫和幼虫大脑中的性别特异性基因，以利用基因组的功能注释，并应用生物信息学技术的全部力量。这些信息将使我能够扩大实验和分析的广度，以研究慈鱼的性别角色行为和优势地位。除了进化论方面的影响，这些研究还将提供进一步的假说，以通过功能分析进行检验。