Clinical Studies in Nutrition and Metabolism

营养与代谢临床研究

• 批准号: 7011263
• 负责人: Ishwarlal Jialal
• 金额: $ 14.27万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7011263
• 关键词: alternative medicine; antihypercholesterolemic agent; antioxidants; atherosclerosis; blood lipoprotein metabolism; cell adhesion molecules; clinical research; dietary lipid; dietary supplements; disease /disorder proneness /risk; flavonoids; human subject; inflammation; leukocyte activation /transformation; lipoxygenase; low density lipoprotein; nuclear factor kappa beta; nutrition related tag; oxidative stress; plant extracts; postgraduate education; protein kinase C; racial /ethnic difference; tocopherols; unsaturated fatty acids

DESCRIPTION (provided by applicant): Cardiovascular disease is the leading cause of morbidity and mortality in the United States. Oxidative Stress and Inflammation play a pivotal role in atherogenesis. CANDIDATE: In the funded K24 Award (Year 4), the principal investigator has made excellent progress with respect to productivity (publications and procuring grants), mentoring and enhancing his research program. RESEARCH PLAN: In the present proposal, which aims to further strengthen his research program and mentoring in patient-oriented research, the principal investigator proposes the following studies: 1) The Effect of High dose Alpha tocopherol Supplementation on Oxidative Stress (OS), Inflammation and Carotid Atherosclerosis in Patients with Coronary artery disease ; 2) Monocyte Function and Inflammation in Type 1 Diabetes and its Modulation with Simvastatin therapy; 3) The Effect of Simvastatin Therapy on Monocytic Inflammatory Markers and hsCRP Levels in Patients with the Metabolic Syndrome; 4) A Dose-Response Effect of Lycopene supplementation on Biomarkers of OS; 5) Effect of Alpha tocopherol and Gamma tocopherol Supplementation on Biomarkers of OS and Inflammation in Patients with the Metabolic Syndrome. Biomarkers of OS that will be analyzed include urinary F2-isoprostanes, LDL oxidative susceptibility; biomarkers of inflammation will include hs-CRP, SAA, plasma soluble cell adhesion molecules, monocyte superoxide anion release, cytokine release, adhesion to endothelium. MENTORING PLAN: These focused and cohesive clinical studies in Nutrition and Metabolism, in addition to the didactic courses and Mentored Clinical Research Training Program offered at UC-Davis will provide an excellent training ground for the junior faculty and clinical fellows in the area of patient-oriented research. Thus, studies outlined in this proposal will clearly enhance the long-term objectives of the principal investigator, since his major interest is in the area of lipoproteins, oxidative stress and inflammation in diabetes and atherosclerosis and their modulation.

描述（由申请人提供）：心血管疾病是美国发病率和死亡率的主要原因。氧化应激和炎症在动脉粥样硬化中起关键作用。候选人：在资助的K24奖（第4年）中，首席研究员在生产力（出版物和采购赠款），指导和增强其研究计划方面取得了出色的进步。研究计划：在本提案中，旨在进一步加强其研究计划并在以患者为导向的研究中进行指导，首席研究者提出了以下研究：1）高剂量α-抗磷灰岩​​补充氧化应激对氧化应激（OS），炎症和颈动脉粥样硬化对冠状动脉疾病患者的影响； 2）单核细胞功能和1型糖尿病的炎症及其对辛伐他汀治疗的调节； 3）辛伐他汀治疗对代谢综合征患者单核细胞炎症标志物和HSCRP水平的影响； 4）补充番茄红素对OS生物标志物的剂量反应效应； 5）代谢综合征患者的OS和炎症生物标志物的α-生育酚和伽马生育酚对OS和炎症的影响。将进行分析的OS的生物标志物包括尿F2-异前体，LDL氧化敏感性；炎症的生物标志物将包括HS-CRP，SAA，血浆可溶性细胞粘附分子，单核细胞超氧化物阴离子释放，细胞因子释放，对内皮的粘附。指导计划：除教学课程和指导的临床研究培训计划外，在UC-DAVIS提供的教学课程和指导的临床研究培训计划外，还为初级教师和面向患者研究领域的临床研究员提供了良好的培训理由。因此，该提案中概述的研究将明确提高主要研究者的长期目标，因为他的主要兴趣是脂蛋白，糖尿病和动脉粥样硬化及其调节的脂肪蛋白，氧化应激和炎症。