Augmentation of molecular machines with new functionalities

分子机器的新功能增强

• 批准号: 2615052
• 金额: --
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2615052
• 关键词: Augmentation; molecular; machines; new; functionalities

Molecular machines like DNA/RNA polymerases, ribosomes and enzymes are central to the function of every living cell, underpinning critical tasks covering the expression of the genetic code to coordination of metabolism. When engineering biology there is often the need to supplement these core activities with new functionalities - "augmenting" the biology in a desired way. While fusion with a protein able to provide the new function can sometimes achieve this goal, this approach is inflexible and doesn't offer a quick and easy way to switch the desired function. It is also doesn't generally allow for placement of a new functionality within the structure of the molecular machine itself.

DNA/RNA聚合酶、核糖体和酶等分子机器是每个活细胞功能的核心，支撑着包括遗传密码表达到新陈代谢协调的关键任务。在工程生物学中，通常需要用新的功能来补充这些核心活动-以期望的方式“增强”生物学。虽然与能够提供新功能的蛋白质融合有时可以实现这一目标，但这种方法是不灵活的，并且没有提供快速简便的方法来切换所需的功能。它通常也不允许在分子机器本身的结构中放置新的功能。