Research Training in Disability & Disabling Disorders

描述(由申请人提供)： 这一以患者为中心的研究的职业生涯中期奖的具体目标是：(1)进一步建立候选人在社区老年人中的流行病学和残疾预防方面的独立以患者为中心的研究计划；以及(2)为正在从事与残疾和致残障碍相关的以患者为中心的老龄化研究的跨学科初级调查人员建立正式的导师计划。这包括一般的功能评估以及高度流行的疾病特定情况的功能后果，如关节炎、心脏病、糖尿病、中风、癌症、抑郁症和痴呆症。候选人的最终目标是在与残疾和致残障碍相关的以患者为导向的研究中建立一个主要项目。在过去的十年里，候选人建立了一个非常成功和独立的以患者为中心的研究计划，解决与流行病和预防有关的基本问题。 残疾。K24奖将允许候选人通过给予他有保障的时间来完成本申请中提出的以患者为中心的研究项目，从而进一步推进这一严重和普遍存在的老年医学问题的科学知识基础。反过来，这一研究计划将为候选人大大扩展的导师计划提供平台，该计划将包括教学培训、实践研究指导和研究基础设施(数据分析和研究助理支持)。候选人计划在头两年每年接受两到三名初级调查人员进入该项目。随后，每年接受的候选人人数将有所不同，以实现任何时候都有5至6名在职受训人员的最终目标。耶鲁大学的环境提供了理想的环境，充满了跨学科的研究和培训计划、跨学科的专业知识和合作，以及资源(例如，方法学咨询、生物统计学支持、访问研究人群和数据库)，以培养候选人、拟议的研究项目和导师计划。总之，候选人在以患者为导向的研究方面的成就，他指导初级调查人员的能力和承诺，以及耶鲁大学的研究和培训优势，共同为成功实现这项提案的具体目标提供了理想的背景。

DESCRIPTION (provided by applicant): The specific aims of this Midcareer Investigator Award in Patient-oriented Research are: (1) to further establish the candidate's independent patient-oriented research program in the epidemiology and prevention of disability among community-living older persons; and (2) to establish a formal mentorship program for junior investigators, across disciplines, who are pursuing patient-oriented aging research related to disability and disabling disorders. This includes functional assessment in general as well as the functional consequences of highly prevalent disease-specific conditions such as arthritis, heart disease, diabetes, stroke, cancer, depression, and dementia. The candidate's ultimate objective is to build a premier program in patient-oriented research related to disability and disabling disorders. During the past ten years, the candidate has established a highly successful and independent patient-oriented research program addressing fundamental issues related to the epidemiology and prevention of disability. A K24 Award will permit the candidate to further advance the scientific knowledge base of this serious and pervasive problem in geriatric medicine by affording him the protected time to complete the patient-oriented research projects proposed in this application. This program of research, in turn, will provide the platform for the candidate's greatly expanded mentorship program, which will include didactic training, hands-on research mentorship, and a research infrastructure (data analytic and research assistant support). The candidate plans to accept two to three junior investigators into the program during each of the first two years. Subsequently, the number of accepted candidates per year will vary to achieve the ultimate goal of having 5 to 6 active trainees at any one time. The Yale environment provides the ideal setting, replete with interdisciplinary research and training programs, interdisciplinary expertise and collaboration, and resources (e.g., methodological consultation, biostatistical support, access to study populations and databases) to foster the candidate, the proposed research projects, and the mentorship program. In summary, the candidate's accomplishments in patient-oriented research, his ability and commitment to mentoring junior investigators, and the research and training strengths of Yale combine to provide an ideal context for successfully carrying out the specific aims of this proposal.