Improvement of University of Oregon Animal Research Facilities

描述(由申请人提供)：我们的目标是扩大和翻新俄勒冈大学(UO)的核心动物设施，以提高PHS资助的研究的生产率和影响，促进研究动物、研究人员和动物护理人员的安全和福利，并扩大全基因组研究的冷冻保存库。UO是利用鱼类模型研究脊椎动物发育、遗传学、基因组学、进化和人类疾病遗传贡献的先驱。由于这种专业知识，UO拥有斑马鱼国际资源中心(ZIRC)。密歇根大学已经开始将这些模型中的发现转化为哺乳动物，并在老鼠遗传学方面开展了一项雄心勃勃的计划，涉及新员工和现有的初级和高级教职员工。UO研究项目的成功给斑马鱼、Stickleback和Mouse设施以及Zirc带来了严重压力。我们建议通过建筑、翻新和设备采购的协同计划来缓解这一压力，包括创新的可持续设计战略，以增加能源节约。(1)我们建议在我们的斑马鱼设施内新建、翻新和购买新的水产养殖设备。这将增加我们可以维护的线路数量，提高工作流程效率。(2)我们建议翻新现有空间和购置新设备，以建立一个新的Stickleback设施。新设施将补充我们现有的非常小的设施，该设施容纳了世界上唯一的近交系，增加了我们可以维护的品系数量，并改善了工作流程。(3)我们建议为UO正在建造的一栋大楼内的新鼠标设施购买设备。这将增加我们可以维持的线路数量，减轻小鼠的压力，并使几名资深教员能够扩大他们的研究计划，将小鼠包括在内。(4)我们建议为ZIRC购买新的冷冻保存设备。这些设备将安置在UO正在建设的一栋毗邻Zirc的大楼内。最近的技术突破使研究人员能够对每个斑马鱼基因进行突变和功能注释。新设备将允许Zirc从这一努力创造的大量遗传和基因组资源中冷冻保存精子。

DESCRIPTION (provided by applicant): Our goal is to expand and renovate core animal facilities at the University of Oregon (UO) to increase productivity and impact of PHS funded research, promote safety and welfare of research animals, researchers, and animal care staff, and expand a cryopreservation repository for genome-wide research. The UO is a pioneer in using fish models for research in vertebrate development, genetics, genomics, evolution, and genetic contributions to human disease. Because of this expertise, UO houses the Zebrafish International Resource Center (ZIRC). UO has begun to translate discoveries made in these models into mammals, with an ambitious program in mouse genetics, involving new hires and current junior and senior faculty. The success of UO research programs has put serious pressure on the Zebrafish, Stickleback, and Mouse Facilities, and on ZIRC. We propose to alleviate this pressure by a synergistic program of construction, renovation, and equipment purchase, including innovative sustainable design strategies to increase energy savings. (1) We propose new construction, renovation, and purchase of new aquaculture equipment in our Zebrafish Facility. This will increase the number of lines we can maintain and improve work flow efficiency. (2) We propose renovation of existing space and purchase of new equipment to establish a new Stickleback Facility. The new facility will complement our very small existing facility that houses the only inbred lines worldwide, increase the number of lines we can maintain, and improve work flow. (3) We propose to purchase equipment for a new Mouse Facility in a building UO is constructing. This will increase the number of lines we can maintain, alleviate stress on the mice, and enable several senior faculty to expand their research programs to include mice. (4) We propose to purchase new cryopreservation equipment for ZIRC. This equipment will be housed in a building UO is constructing adjacent to ZIRC. Recent technological breakthroughs are enabling researchers to mutate and functionally annotate every zebrafish gene. The new equipment will allow ZIRC to cryopreserve sperm from the extensive genetic and genomic resources created by this effort.