Neuroscience and Health Annex on the Coral Gables Campus at the University of Mia

描述(由申请人提供)：为了促进在最先进的实验室设施中进行有效的变革性合作研究，我们提议在迈阿密大学珊瑚山墙校区的考克斯科学大楼基础上新建一座37,700平方英尺的新建筑(神经科学和健康附属设施)。神经科学和健康附件将为需要复杂图像分析的研究中的大脑、行为和健康这一跨学科研究主题的研究人员创建一个互动的“中心”。计划中的神经科学和健康附件包括基于生物成像和健康研究的多个相互关联的焦点。在每个研究重点(例如，千叶/高级分子成像、施奈德曼/健康心理学/行为医学研究、萨科和莫德斯利/功能磁共振脑成像)，都有由NIH资助的高级研究人员。这些重点得到了一个协作研究空间系统的支持，该系统旨在容纳多项研究工作所需的资源。该附属设施将为功能磁共振成像核心实验室、先进的原位分子成像复合体和隔膜提供设施。它将整合行为研究人员，并使他们彼此密切联系，并与太空中专门为他们的研究需求设计的其他神经科学家保持密切联系。该附属建筑的设计和建造将遵循美国绿色建筑委员会的可持续设计标准，以实现LEED银牌认证的目标。该大学承诺提供资金以完成该项目并购买功能磁共振磁体。该项目的资金预计将为美国创造189个就业机会(174个工业就业机会和15个学术就业机会)，并得到大学领导层的全力支持。 公共卫生相关性(由申请人提供)：神经科学的最大前沿是了解神经系统中的分子变化如何与行为相关，并确定神经系统中可预测神经系统疾病成功治疗的不同分子模式，在某些情况下可导致受损脊髓或大脑的成功再生。神经科学与健康附件中的研究项目将通过研究动物模型系统来为这一努力做出贡献，并将人类行为与大脑不同区域的功能变化联系起来。

DESCRIPTION (provided by applicant): To promote effective transformational collaborative research in state-of-the art laboratory facilities, we propose to build a 37,700 sq ft addition (Neuroscience and Health Annex) to the Cox Science Building on the Coral Gables campus at the University of Miami. The Neuroscience and Health Annex will create an interactive "hub" for researchers on the interdisciplinary research theme of Brain, Behavior and Health in studies requiring sophisticated image analysis. The planned Neuroscience and Health Annex comprises multiple interlinked foci based on biological imaging and health research. There are senior NIH-funded investigators in each of the research foci (e.g., Chiba/Advanced Molecular Imaging, Schneiderman/Health Psychology/ Behavioral Medicine Research, Sacco and Maudsley/fMRI Brain Imaging). These foci are supported by a system of collaborative research spaces designed to house resources needed for multiple research endeavors. The annex will provide facilities for a fMRI core laboratory, an advanced in situ molecular imaging complex and a vivarium. It will consolidate behavioral researchers and will bring them into close contact with one another and with other neuroscientists in space specifically designed for their research needs. The annex will be designed and built following US Green Building Council sustainable design criteria with the goal of achieving LEED Silver Certification. The University is committed to providing funds to complete the project and to purchase a fMRI magnet. Funding of this project is expected to generate 189 American jobs (174 industrial and 15 academic) and has full support of the university leadership. PUBLIC HEALTH RELEVANCE (provided by the applicant): The great frontier for neuroscience is to understand how molecular changes in the nervous system relate to behavior and to identify different molecular patterns in the nervous system that can predict successful treatment of neurological diseases and in some cases lead to successful regeneration of damaged spinal cord or brain. The research programs in the Neuroscience and Health Annex will contribute to this effort by studying model systems in animals and correlate human behavior with functional changes in different regions of the brain.